急性冠脉综合征患者血清hs-CRP、BNP和cTNI检测的临床意义

The clinical significance of serum hs-CRP, BNP and cTNI in patients with acute coronary syndrome

目的 探讨高敏C反应蛋白（hs-CRP）、脑钠肽（BNP）和心肌肌钙蛋白Ⅰ（cTNⅠ）在急性冠状动脉综合征（ACS）患者血清中的表达水平及其检测的临床意义.方法 我科收治的ACS患者43例（ACS组）和健康查体者46例（对照组）作为研究对象.酶联免疫吸附法检测上述患者血清CRP、BNP和cTNⅠ水平,比较两组患者血清hs-CRP、BNP及cTNⅠ水平有无差异及其在ACS组患者中的相关性.结果 ACS组血浆hs-CRP、BNP和cTNⅠ分别为（6.88±2.11） mg/L,（311.6±88.9） pg/ml和（17.4±9.1） pg/ml;对照组分另别为（2.67±1.12） mg/L,（21.8±8.9） pg/ml和（0.14±0.10） pg/ml,ACS组上述指标均显著高于对照组,差异有统计学意义（P＜0.05）;ACS组患者血浆hs-CRP、BNP与cTNⅠ之间存在正相关,pearson相关系数r分别为0.81（P＜ 0.05）和0.47（P＜0.05）.结论 ACS患者血清hs-CRP、BNP和cTNⅠ显著升高,且三者间存在相关性,可作为临床诊断ACS的血清学标志物.

Objective To evaluate the clinical significance of serum hs-CRP, BNP and cTNI in patients with acute coronary syndrome. Methods 43 cases of ACS and 46 health examinees in our hospital were recruited as study object. The serum levels of hs-CRP, BNP and cTNI were tested by ELISA and compared between two groups. Results The serum levels of hs-CRP, BNP and cTNI in ACS group were （6.88 ± 2.11） mg/L, （311.6 ± 88.9） pg/ml and （17.4 ± 9.1） pg/ml respectively, those in control group were （2.67 ± 1.12） mg/L, （21.8 ± 8.9） pg/ml, （0.14 ± 0.10） pg/ml respectively. The serum levels of hs-CRP, BNP and eTNI in ACS group were signifieantly higher than those in control group （P 〈 0.05）. The serum level of cTNI in patients with ACS was related to the serum levels of hs-CRP and BNP, with Pearson correlation coefficients of 0.81 and 0.47 （P 〈 0.05）. Conclusions The serum levels of hs-CRP, BNP and cTNI in patients with ACS are significantly increased, whieh can be used as serum biomarker for the diagnosis of ACS.