红细胞输注效果与免疫系统变化相关性研究

目的探讨红细胞输注效果与免疫系统变化的关系。方法选择慢性再生障碍性贫血患者(CAA)、肺癌患者以及肝癌患者作为研究病例,并依据红细胞输注24 h后的血红蛋白含量将患者分为观察组(25例)与对照组(25例),应用酶联免疫法分别测定患者输血前后的血清含量包括(IgG、IgA、IgM)同时测定补体C3、C4含量。结果观察组肝癌与CAA患者的在输血后其血清IgG、IgA升高明显(P<0.05),肺癌患者输血前后比较,其血清IgG、C3差异有统计学意义(P<0.05),肺癌患者、肝癌患者及CAA患者的对照组在输血前后免疫球蛋白与补体变化,差异无统计学意义(P>0.05)。结论红细胞输注效果欠佳与患者机体的免疫系统变化有一定的关系,故此应综合考虑具体情况选择输血方法。

Objective To explore the relationship between red blood cell transfusion effects and changes in the immune system.Methods The patients with chronic aplastic anemia （CAA）,lung cancer as well as the patients with hepatocellular carcinoma were chosen as a research object, and basis for the hemoglobin content in the after the with infusion of red blood cell is 24 h will patients were divided into observation group （25 cases） and control group （25 cases）. The serum levels include lower levels of （IgG,IgA,IgM） and complement C 3,C 4 content of at the same time. were determined using enzyme-linked immunosorbent method before and after the blood transfusion.Results Serum IgG,IgA increased significantly in patients with CAA and liver cancer observation group in the post-transfusion （P0.05）.Conclusion Red blood cell transfusion is ineffective and the patient＇s body have a certain relationship to the changes in the immune system and therefore should be taken into account the specific circumstances to select the method of blood transfusion.