空气污染与心血管疾病发病及预后的研究进展

Advance in research on exposure to particulate matter air pollution and cardiovascular disease

近年来以细颗粒物(PM2.5)为代表的可吸入颗粒物(PM)日益被视为全球空气污染相关死亡率升高的主要原因。有确凿的证据支持炎症、氧化应激、动脉粥样硬化、血栓形成以及自主调节异常等多种机制的相互作用,最终可增加短期及长期接触污染空气人群心血管疾病发病率与死亡率。空气污染带来的心血管风险是可以部分规避的。

AIM：Particulate matters in inhaled air are increasingly considered as the main culprit for the pollutionrelated increase in global mortality, particularly the smaller particles of 〈2.5 μm in aerodynamic diameter. There is unequivocal evidence that mechanisms such as inflammation, oxidative stress, atherosclerosis, thrombogenesis and autonomic dysregulation interplay to increase cardiovascular mortality and morbidity in persons exposed acutely and chronically to air pollution. Increased cardiovascular risks related to air pollution, however, could be avoided to some extent.