黄芪注射液联合红霉素治疗小儿支原体肺炎的疗效

Effects of radix astragali injection and erythromycin on mycoplasma pneumonia in children

目的:探讨黄芪注射液联合红霉素治疗小儿支原体肺炎的临床效果及其安全性。方法:将2009年5月至2012年5月惠州市中心人民医院收治的270例支原体肺炎患儿随机分成3组:阿奇霉素组、红霉素组和联合组(黄芪注射液联用红霉素),每组90例。比较3组临床疗效、主要临床症状缓解消失时间、住院时间及不良反应发生的情况。结果:联合组痊愈率(77.8%)、总有效率(95.6%)高于红霉素组和阿奇霉素组的44.4%、82.2%和64.4%、92.2%(P<0.05):联合组症状体征缓解消失时间及住院时间短于红霉素组和阿奇霉素组(P<0.05):联合组不良反应率发生率最低(3.3%),其次为阿奇霉素组(11.1%),红霉素组最高(27.8%)。结论:黄芪注射液联合红霉素治疗小儿支原体肺炎疗效肯定,可缩短病程,减少不良反应的发生率。

Objective： To determine the efficacy and safety of radix astragali injection and erythromycin on mye, oplasma pneumonia in children, Methods ： We randomly allocated 270 children with mycoplasma pnemnonia admitted to Huizhou Central People＇s Hospital between May 2009 and May 2012 to azithromycin group （n = 90）, euthromycin group （n= 90） and combined treatment （radix astragali injection and erythromycin） group （n = 90）, respectively. The time to recoveU of major symptoms, hospital day and incidence of adverse reactions were compared, Results： The combined tlatment group yielded a higher recovery （77.8%） and effectiveness rate （95.6% vs. 44.4% and 82.2% ） compared with erythrmnycin group and azithromycin group （all P 〈 0.05 ）. The combined treatment group was also associated with a shorter time to recovery of symptoms and reduced hospital stay compared with erythromycin group and azithromycin group （ all P 〈 0.05 ）. The incidence of adverse reactions was lowest in combined treatment group （3.3%）, tollowed by azithromycin group （11. 1% ） and erythromycin group （27.8%）. Conclusion： The combination of Radix astragali injection and erythromycin is effective for the treatment of mycoplasma pneumonia in children in terms of the shortened duration of symptoms and reduced incidence of adverse reactions.