尼卡地平预防双腔支气管导管插管反应的观察

Preventive effect of nicardipine on cardiovascular reponses to bronchial intubation with double channel catheter

目的 观察应用尼卡地平预防双腔支气管导管插管心血管反应的效果。 方法 肺、食道择期手术病人 40例 ,随机分为 2组 ,每组 2 0例。咪唑安定 0 .0 4mg/kg、异丙酚 1.5mg/kg、芬太尼 4μg/kg、维库溴铵 0 .12mg/kg静脉诱导后 ,甲组给予尼卡地平 4μg/kg ,乙组给予生理盐水 3ml作为对照。分别于诱导前、后 ,插管后即刻及 1、3、5min监测收缩压 (SBP)、舒张压 (DBP)、心率 (HR) ,并计算心率收缩压乘积 (RPP)。 结果 A组插管后血压无明显升高 ,心率较诱导前无明显增快 ,B组插管后血压明显升高。 结论 尼卡地平可抑制双腔支气管导管插管时的心血管副反应。

objective To observe the effect of nicardipine on the cardiovascular responses to bronchial intubation with double channel catheter. Methods Forty patients undergoing lung or esophagus operation were divided randomly into 2 groups,with 20 cases each.After venous induction with midazolam 0.04mg/kg,propofol 1.5mg/kg,fentanyl 0.3 mg/kg,vecuronium bromide 0.12mg/kg,patients in group A received nicardipine 4μg/kg,normal saline 3ml in group B,catheter was inserted.Systolic blood pressure(SBP),diastolic blood pressure(DBP),heart rate(HR)and ratepressure product(RPP)were measured and calculated before and after induction,immediately and 1,3,5minutes after intubation. Results After intubation,SBP,DBP,HP,RPP in group A did not increase,but in group B they increase evidently. Conclusion Nicardipine can prevent the cardiovascular responses to bronchial intubation with double channel catheler.