间日疟原虫裂殖子表面蛋白3α基因多态性的研究进展

Research Progress on Polymorphism in the Merozoite Surface Protein-3α Gene of Plasmodium Vivax

间日疟原虫裂殖子表面蛋白3α(Plasmodium vivax merozoite surface protein-3α,PvMSP-3α)是红内期间日疟原虫裂殖子形态的一种表面蛋白。PvMSP-3α基因在世界范围内具有高度基因多态性,是对间日疟原虫进行基因分型和流行病学研究较合适的分子标记物,为开发抗疟疫苗提供了重要候选抗原。本文就PvMSP-3α的分子结构、基因多态性和基因分型作一综述。

The merozoite surface protein-3α of Plasmodium vivax （PvMSP-3α） is a surface protein that is expressed during the asexual blood stages. With a high polymorphism, PvMSP-3αgene has been used as a suitable epidemiology and genotype marker. Moreover, it might be an important malaria vaccine candidate. This paper summarizes the research progress on the molecular structure, gene polymorphism and genotypes of PvMSP-3α.