高血压患者左心室肥厚与QT离散度增大

Left ventricular hypertrophy and QT dispersion increase in patients with hypertension

目的 进一步探讨高血压左心室肥厚及左心室质量增大与 QT离散度 (QTdispersion,QTd)改变的关系。方法 采用 12导联心电图同步描记及心脏超声检查等方法对 94例原发性高血压患者 [男性 40例 ,女性 5 4例 ,年龄 (5 9.9± 11.2 )岁 ]和 11例正常人 [男性 4例 ,女性 7例 ,年龄 (5 2 .8±16 .9)岁 ]作 QTd及左心室肥厚、左心室质量检测分析。结果 高血压左心室肥厚组 ( 组 ,n=6 2 ) QTd较非肥厚组 ( 组 ,n=32 )以及正常对照组 ( 组 ,n=11)均明显增大 (P<0 .0 1～ 0 .5 0 ) ,QTd与左心室质量呈正相关 (r=0 .47,P<0 .0 1)。结论 原发性高血压左心室肥厚、左心室质量增大可使 QTd明显增大 ,具有心室肌复极不均一。

Objective To study the relationship between hypertensive left ventricular hypertrophy and QT dispersion (QTd). Methods QTd and left ventricular thickness and mass were measured by 12 lead synchronously recording ECG and echocardiogram in 94 primary hypertension patients [male=40,female=54,age=(59 9±11 2) years] and 11 normal subjects [male=4,female=7,age=(52 8±16 9) years]. Results The QTd of the patients ( n= 62) with ventricular hypertrophy was significantly larger than that of the patients ( n =32) without ventricular hypertrophy and the normal subjects ( P< 0 01).QTd were directly related to ventricular mass ( r=0 5,P <0 01). Conclusion QTd may be increased significantly by hypertensive ventricular hypertrophy and ventricular mass increasing which would form the functional basis for ventricular asynchronous repolariz[WT5”,6BZ]ation,and increase the potential risk of leading to reentrant ventricular arrhythmias and sudden death.