8-异前列腺素F2α在损伤性肝脏疾病中的作用与机制

Role and action mechanism of 8-iso-PGF2α in traumatic liver diseases

活性氧自由基引发的氧化应激主要通过启动膜脂质过氧化反应改变生物膜的功能,并在一系列细胞因子的共同作用下引起不同程度的肝损害。8-iso-PGF2α是脂质过氧化反应的特异性产物,具有很强的生物学活性,目前被认为是评价氧化应激和脂质过氧化损伤的金指标。文章简述了损伤性肝脏疾病与脂质过氧化的关系,并提出以8-iso-PGF2α作为肝脏疾病过氧化损伤程度的敏感指标,初步探讨了其在肝脏疾病中的应用前景。

Oxidative stress caused by reactive oxygen species changes the function of biofilm mainly by initiating membrane lipid peroxida- tion and causes varying degrees of liver damage along with a series of cytokines. As the specific product of lipid peroxidation, 8 - iso - PGF2α has strong bioactivity and is currently considered the gold indicator for evaluating oxidative stress and lipid peroxidation damage. The relationship between traumatic liver diseases and lipid peroxidation is summarized; 8 -iso -PGF2α is recommended as a sensitive indicator of peroxidative damage in liver diseases, and its potential use in liver diseases is preliminarily discussed.