口服普萘洛尔治疗婴儿型血管瘤的效果观察

Clinical efficacy of propranolol treatment in infantile hemangiomas

目的 观察口服小剂量普萘洛尔治疗婴儿血管瘤的疗效及其用药的安全性.方法 2010年～2013年间,选取月龄在12月内的血管瘤患儿57例（其中5例为Kasabach-Merritt综合征患儿,2例为注射平阳霉素后血管瘤体感染坏死患儿）,通过口服小剂量普萘洛尔（1mg/kg,分2次口服）治疗婴儿血管瘤,观察治疗效果及有无并发症发生.结果 经住院1周观察,57例患儿血管瘤体均显著缩小,出院后继续服药随访1个月,血管瘤均仍有进一步缩小趋势;服药期间患儿心率均下降,部分患儿出现皮疹、腹泻等症状,未发生严重的并发症.结论 通过口服普萘洛尔,可使血管瘤瘤体较前明显缩小,达到治疗效果,且较少引起并发症.

Objective To observe the efficacy and safety of low-dose oral propranolol therapy for infantile hemangioma.Methods 57 infantile patients with hemangiomas of proliferative phase treated in our department were collected from 2010 to2013,including 5 patients with Kasabach-Merritt Syndrome; 2 patients with vascular tumors were infected necrosis after injection of pingyangmycin.To observe the efficacy and complications of the patients were treated hemangiomas by oral low-dose of propranolol.Results The size of the hemangiomas in 57 infantile patients were reduced,and most of them were tending to be reduced in two months.The heart rate of all patients had declined after oral propranolol therapy,and erythra and diarrhea occurred in few patients.Serious complications were not found.Conclusion Propranolol therapy has a certain inhibitory effect in infantile hemangiomas.Few significant side effects of propranolol is found.