65例慢性阻塞性肺疾病患者血降钙素原变化分析

The chronic obstructive pulmonary disease blood procalcitonin (PCT) change:An analysis of 65 cases

目的分析65例慢性阻塞性肺疾病急性加重期(AECOPD)患者血清降钙素原变化及其指导意义。方法本研究纳入65例AECOPD患者,随机分成A组(PCT指导组)、B组(一般治疗组)。A组按患者血PCT高低及变化判断抗生素的使用时间;B组根据患者临床症状判断抗生素的使用时间。分别记录A、B两组抗生素的使用时间、住院天数、临床有效率,加重例数和死亡例数用于评估。结果 A组的抗生素使用时间多为7～10 d:B组大多数为2周以上,二者有明显差异(P<0.05);A、B两组住院时间也存在显著差异(P<0.05)。结论 PCT在AECOPD患者治疗中,具有指导意义,能够有效缩短抗生素使用时间及缩短住院天数。

Objective To analyze the blood procalcitonin change in patients with acute exacerbation chronic obstruc- tive pulmonary disease （AECOPD） and its clinical significance. Methods The study included 65 patients with AE- COPD, were randomly divided into A group （PCT group）, B group （conventional therapy group）. A group according to the level of PCT patients and change of antibiotic use time; B group according to the clinical symptoms of patients with antibiotic use time of judgment. Recorded A, B two group, antibiotic use time, hospitalization days, clinical effec- tive rate, increase of cases and death cases used in the evaluation. Results The length of antibiotic exposure in PCT group was 7-10 days,while that in standardtherapy group was more than 2 weeks （P〈0.05）. There were a significant difference of the length of hospitalization between the two groups （P〈0.05）. Conclusion Procalcitonin guidance for AECOPD Can reduce the dose of antibiotic drugs and the length of hospitalization.