咪唑安定在椎管内麻醉中的应用价值分析

Analysis of the application value of Midazolam on intravertebral anesthesia

目的探讨咪唑安定用于椎管内麻醉的临床应用价值。方法分析我院自2010年4月～2013年1月收治的56例行椎管内麻醉的妇科手术患者,按照随机数字表法分为对照组28例,给予芬太尼静滴,治疗组28例,给予芬太尼与咪唑安定静滴,比较两组患者镇静、遗忘程度。结果①对照组与治疗组完全遗忘率分别为39.3%(11/28)和67.8%(19/28);不全遗忘比率分别为35.7%(10/28),25.0%(7/28)和无遗忘比率分别为28.6%(8/28)和3.6%(1/28);两组患者遗忘率(完全遗忘率+不完全遗忘率)比较(χ2=6.85,P<0.05)。②镇静程度0级、I级、Ⅱ级、Ⅲ级对照组分别为10.7%、53.6%、32.1%、3.6%,治疗组分别为3.6%、21.4%、57.1%、17.9%,两组比较(χ2=9.46,P<0.05)。结论咪唑安定用于椎管内麻醉可以增加镇静程度及遗忘程度,疗效确切,值得临床应用推广。

[Abstract] Objective To explore the application value of Midazolam on intravertebral anesthesia. Methods Fifty-six patients with gynecological operation and spinal anesthesia in our hospital from 2010 April to 2013 January were divided into two group by random digits table. The control group （28 cases） was treated by fentanyl intravenous drip and the treatment group （28 cases） was treated by fentanyl and midazolam. The sedation and amnesia degree in two groups were compared. Results （!）The completely forgetting rates in two groups were 39.3% （11/28） and 67.8% （19/28）; The incomplete amnesia rates in two groups were 35.7% （10/28）,25.0% （7/28）;The rates of without forgetting were 28.6%（8/28） ,3.6%（1/28）;There was significant difference between two groups （X2=6.85,P〈0.05）. @）The degrees of sedation grade 0,grade I ,grade I1 ,grade III in control group were 10.7% ,53.6% ,32.1% ,3.6%. The degrees in treatment group were 3.6%,21.4%,57.1%,17.9% ,there was significant difference between two groups （X2=9.46,P〈0.05）. Conclusion Application of Midazolam in intravertebral anesthesia can increase the degrees of sedation and amnesia. The curative effect of Midazolam is exact, and worthy of clinical application.