IL-6在急性胰腺炎中与肝功能损害的关系

Relationship of IL-6 in the acute pancreatitis with hepatic function damage

目的观察急性胰腺炎肝损害患者血浆中IL-6、ALT、AST含量变化,探讨IL-6在肝损害发生、发展中的临床意义。方法选取非胆源性急性胰腺炎合并肝功能损害患者71例,按CT分级分为轻型组、重症组,健康成人30例做为对照组。采用放射免疫学法及化学发光法检测其血浆中IL-6、ALT、AST含量变化,进行统计学分析。结果轻型胰腺炎和重型胰腺炎血浆中IL-6、ALT、AST含量检测值均高于对照组,重型胰腺炎高于轻型胰腺炎,均有统计学意义。结论 IL-6从加速肝细胞凋亡,扩大肝脏炎症反应,破坏肝血管微循环等诸多方面导致肝脏功能受损,加重胰腺炎的病情。

Objective To observe the content change of IL-6, ALT, AST and to investigate the relationship between IL-6 and the hepatic function damage. Methods Selected 71 cases of non-biliary acute pancreatitis with hepatic le- sion patients, according to CT grading divided into the mild acute pancreatitis group（MAP） and severe acute pancreati- tis group （SAP）, selected 30 cases of healthy adults as the control group. By using radioimmunoassay and chemilumi- nescence, tested content changes of IL-6, ALT, AST, then statistical analysis was conducted. Results IL-6, ALT, AST of MAP and SAP plasma IL-6, ALT, AST, were higher than those in the control group, all had statistical significance. Conclusion IL-6 through accelerating hepatic cell apoptosis, expanding inflammation response to damage hepatic mi- crocirculation, aggravate the disease of pancreatitis.