不同类型子痫前期孕妇四项血小板参数的变化规律和临床意义

The changes of four platelet parameters and clinical significance in women with different types of preeclampsia

目的 探讨不同类型子痫前期孕妇四项血小板参数的变化规律和临床意义. 方法随机选取44例早发型子痫前期孕妇（早发组）和37例晚发型子痫前期孕妇（晚发组）及40例正常孕妇（对照组）为研究对象,分析妊娠24～32周血小板计数、血小板压积、血小板分布宽度和血小板平均体积的变化规律. 结果孕24～32周,早发组血小板计数最低,而孕29～32周,血小板分布宽度和血小板平均体积明显高于晚发组和对照组,组间比较差异有统计学意义（P ＜ 0.05）;孕29～32周,早发组血小板压积低于晚发组和对照组,差异有统计学意义（P ＜ 0.05）,而晚发组和对照组比较差异无统计学意义（P ＞ 0.05）. 结论早发型子痫前期孕妇自孕24周血小板计数即开始出现减少,其严重程度较晚发型明显,持续监测高危孕妇血小板参数的变化,有助于预测和指导治疗子痫.

Objective To study the change of four platelet parameters and clinical significance in women with different types of preeclampsia. Methods Forty-four cases pregnant women with early-onset preeclampsia （early group）, 37 cases with late-onset preeclampsia （late onset group） and 40 cases of normal pregnant women （control group） were ran- domly selected as the research objects. The changes of platelet count, mean l？latelet volume, platelet distribution width and plateletcrit were analyzed in 24-32 weeks. Results Early group had lowest platelet count in 24-32 weeks, and the platelet volume and platelet distribution were significantly higher than late group and the control group in 29-32 weeks （P 〈 0.05）. The plateletcrit in early group were significant less than late onset group and the control group in 29-32 weeks （P 〈 0.05）, while the late-onset group and control group had no statistical difference （P 〉 0.05）. Con- clusion The disorders of platelet may be more severe in early onset preeclampsia women began at 24 weeks than late onset preeclampsia. Continuous monitoring of platelet parameters in patients with preeclampsia is valuable to evalua- tion the prognosis and treatment of the disease.