青光安有效组份对兔眼滤过性手术后眼压和滤过道瘢痕组织成纤维细胞的影响

Effects of Effective Components of Qingguang'an on Intraocular Pressure and Inoblast of Scarring Tissue of Filtration Canal after Glaucoma Surgery

目的:观察青光安4种有效组份对青光眼术后眼压和滤过道瘢痕组织成纤维细胞的影响,探讨青光安有效组份抗青光眼术后滤过道瘢痕化的效果及作用机制。方法:将青光安有效组份作用于滤过性手术术后兔眼(A.B.C.D组),通过与空白组(A组)、模型组(B组)、MMC组(C组)的比较,观察青光安4种有效组份对青光眼术后眼压和滤过道瘢痕组织成纤维细胞的影响。结果:术后MMC组(C)及有效组份两组(E组)眼压回升缓慢,第4周时眼压仍为最小,该两组眼压值与其他组眼压值比较差异均有统计学意义。成纤维细胞个数组间比较,除组份1组与组份3组组间比较P>0.05,差异无明显统计学意义外,其他各组间比较差异均有意义。结论:(1)青光眼术后滤过道瘢痕化,是导致术后眼压异常回升,滤过性手术失败的重要原因。(2)青光安有效组份2和MMC都可通过抑制成纤维细胞增殖,明显减少瘢痕组织增生,具有明显的抗青光眼术后滤过道瘢痕化的作用。

Objective： To observe effects of four effective components of Qingguang＇ an on intraocular pressure and inoblast of scarring tissue of filtration canal after glaucoma surgery, and to discuss their effect and function mechanism on preventing its formation. Methods ： Four effective components of Qingguang＇ an used in rabbit eyes after glaucoma surgery （D. E. F. G）, with the blank group （A）, model group （B）, MMC group comparison （C）, observing effects of four ef fective components of Qingguang＇ an on intraocular pressure and inoblast of scarring tissue of filtration canal after glauco- ma surgery. Result ： After surgery, MMC group （C） and effective component 2 （E） groups＇ intraocular pressure rose slowly. A! the fourth week,the intraocular pressure remained minimum. The comparison of these two groups＇ intraocular pressure and those of group A, B, D, F and G had significance on statistics. Comparing with the number of inoblast of each group, except group D and E, it had no obvious significance on statistics, P 〉 0.05. Others were significant. Conclusion ： （ 1 ） The scaring of filter canal after glaucoma surgery is the main cause of the filtration surgery＇ s failure as- suming abnormal backup intraocular pressure. （2） The effective component 2 of Qingguang＇ an and MMC can obviously inhibit the multiplication of inoblast, reduce the hypeq^lasia of scar tissue, which has obvious effect for preventing scarring of filtration canal.