胃癌术后早期化疗结合中医辅助治疗的临床观察

Clinical Observation of Early Postoperative Chemotherapy Combined with Traditional Chinese Medicine Adjuvant Therapy for Gastric Carcinoma

目的:观察胃癌术后早期化疗结合中医辅助治疗的临床疗效。方法:将符合标准的198例患者,按随机数字表法分为两组。对照组82例采用化疗和西医常规处理,治疗组116例在对照组基础上,于化疗期间加用中药黄芪注射液,化疗间歇期加用香砂六君子汤加减治疗。结果:治疗后两组WBC、CEA和CA724改变差异均有显著性意义(P<0.05),CA199改变差异无显著性意义(P>0.05)。两组患者全部出现不同程度胃肠道反应。治疗组轻度胃肠道反应78例,占67.24%,重度反应10例,占8.62%。对照组轻度反应12例,占14.63%,重度反应45例,占54.88%。两组比较,差异均有显著性意义(P<0.05)。治疗组明确发生转移者26例,复发12例,复发转移率为32.75%。对照组明确发生转移者30例,复发21例,复发转移率为62.20%。两组比较,差异有显著性意义(P<0.05)。治疗组患者生活质量改善率67.25%,对照组改善率22.41%,差异有显著性意义(P<0.05)。结论:胃癌术后早期化疗期间加用中药黄芪注射液,化疗间歇期加用香砂六君子汤加减治疗,可减轻化疗药物的白细胞的抑制,减轻胃肠道不良反应的程度,减少复发和转移,改善患者生活质量。

Objective：To observe the clinical curative effect of early postoperative chemotherapy combined with adju- vant therapy of traditional Chinese medicine for gastric carcinoma. Methods ：198 patients were conformed standard and di- vided into 2 groups according to random number table method. Control group was 82 cases and used chemotherapy and conventional western medicine treatment, while the treatment group was 116 cases and used the chemotherapy combined with traditional Chinese medicine astragalus membranaceus injection on the basis of control group. During the intermittent period of chemotherapy, Xiangsha Liujunzi Decoction was used. Results： After the treatment in two groups, the WBC, CEA and CA724 changes had significant difference （ P 〈 0.05 ）. CAt99 changes had no significant difference （ P 〉 0. 05）. All patients of two groups appeared different degree of gastrointestinal reaction. Treatment group with mild gastroin- testinal reaction was 78 cases, accounting for 67.24%, 10 cases had severe reactions, accounting for 8.62%. Control group had 12 cases mild effects, accounting for 14. 63%, 45 cases had severe reaction, accounting for 54.88%. Signifi- cant differences were observed in the comparison of two groups （P 〈 0.05）. Treatment group had 26 cases clear shift, 12 cases recurred, and the recurrence metastasis rate was 32.75%. 30 cases of control group clear shifted, 21 cases re- curred, and the recurrence metastasis rate was 62.20%. Comparison of two groups had significant differences （P 〈 0.05）, The improving rate of life quality of period patients in treatment group was 67.25%, and that of control group was 22.41%. There was significant difference （P 〈0. 05 ）. Conclusion： Early postoperative gastric cancer during chemo- therapy combined with traditional Chinese medicine astragalus membranaceus injection, and intermittent period of chemo- therapy added Xiangsha Liujunzi Decoction, can reduce the inhibition of the white blood cells of the chemotherapy drugs, reduce the extent of the gastrointestinal adverse reactions, reduce the recurrence and metastasis, and improve patients quality of life,