盐酸氨溴索对哮喘患儿炎性因子及发作状态的影响

The effects of Ambroxol hydrochloride on seizure status and inflammatory factors in children with asthma

目的探讨盐酸氨溴索在哮喘患儿中的应用效果。方法将本院100例哮喘患儿按照治疗方法的不同分为治疗组和对照组,对照组采用常规疗法治疗,治疗组在对照组的基础上采用盐酸氨溴索治疗,比较两组患儿的炎性因子及哮喘发作情况。结果治疗组患者日间症状积分和夜间症状积分均显著低于对照组,无症状时间长于对照组(P<0.05)。治疗组治疗后炎性因子IL-6、TNF-α、IgE水平显著低于对照组(P<0.05)。结论盐酸氨溴索辅助治疗小儿哮喘能能够显著改善哮喘发作状态,这可能与其降低炎性因子水平有关。

Objective To investigate the effect of ambroxol hydrochloride in children with asthma. Methods 100 cas- es of asthma children were divided into the treatment group and the control group according to different treatment methods, the control group was given conventional therapy, the treatment group were treated with ambroxol hydrochlo- ride based on the control group, seizure status and inflammatory factors were compared between two groups. Results The daytime symptom scores and nocturnal symptom scores in the treatment group were significantly lower than those in the control group, the symptom-free days were longer than that in the control group （P〈0.05）. Inflammatory factor IL-6, TNF- α, IgE in the treatment group was significantly lower than those in the control group （P〈0.05）. Conclu- sion Ambroxol hydrochloride in the treatment of children with asthma can significantly improve asthma attacks, which may be related to the reduction of inflammatory factors.