血清三铁与超敏C反应蛋白的检测在肾性贫血中的意义

Clinical significance of iron-status indices and high-sensitive C-reactive protein in patients with renal anemia

目的探讨肾性贫血患者血清三铁与超敏C反应蛋白的临床诊断价值。方法检测279例已确定为肾性贫血患者的血清三铁（SI、TIBC、TS）及超敏C反应蛋白（hs—CRP）参数，并以200例正常体检者作为对照组，进行t检验和相关性分析。结果肾性贫血组血清三铁各参数均低于正常对照组（P〈O．05），超敏C反应蛋白则高于正常对照组（P〈0．05），肾性贫血组中血清铁与超敏C反应蛋白之间呈负相关关系（r=-0．49，P〈O．01），差异有统计学意义；而正常对照组中，血清三铁与超敏C反应蛋白无相关关系，差异无统计学意义（P〉0．05）。结论检测肾性贫血患者中血清三铁和超敏C反应蛋白参数，对纠正慢性肾功能不全引起的贫血有重要的临床意义。

Objective To investigate the clinical diagnostic value of iron-status indices and high-sensitive C-reactive protein in patients with renal anemia. Methods Iron-status indices （SI,TIBC,TS） and high-sensitive C-reactive protein （hs-CRP） were tested in 279 cases of renal anemia and 200 healthy subjects. T-test and correlation analysis were used to compare. Results Iron-status in- dices （SI,TIBC,TS） in patients with renal anemia were lower than those in healthy subjects（P〈0.05）. On the contrary,high-sen- sitive C-reactive protein in patients was higher than that in healthy subjects （P〈0.0S）. There was a negative correlation between i- ron-status indices and high-sensitive C-reactive protein in patients with renal anemia（r=-0.49 ,P〈0.01） ,which was statisticallysignificant^while there was no correlation between iron.status indices and hypersensitive C-reactive protein in healthy subjects, which was statistically insignificant （P〉O. 05）. Conclusilin Our results suggest that it has significently clinical value to test the i- ron-status indices and high-sensitive C-reactive protein for anemia caused by chronic renal insufficiency.