原发性肝癌术后复发再切除问题探讨

Repeated hepatectomy for recurrent liver cancer

目的 探讨复发性肝癌发现的途径 ,再切除的路径和手术方法 ,再切除的疗效以及影响再切除肝癌预后的因素。方法 研究 5 7例肝癌术后复发的各种发现途径 ,5 7例复发性肝癌进行再切除 ,比较第一次术后的无瘤生存期、再切除术后的生存期、累积生存期以及影响预后的相关因素。结果 复发性肝癌的诊断手段为术后AFP再次升高 36例 (81.8% ) ,CT发现病灶 43例 (87.7% ) ,B超发现病灶 33例 (6 4.7% )。第一次手术后的 1,3,5 ,10年无瘤生存率分别为 6 3.9% ,38.3 % ,2 6 .6 % ,12 .8% ;再切除后的 1,3,5 ,10年生存率为 5 6 .6 % ,37.7% ,31.9% ,16 .2 % ;而 1,3,5和 10年的累积生存率分别为 82 .1% ,6 0 .8% ,47.6 % ,19.5 %。影响再切除预后的因素有肿瘤的大小、数目、复发时间、再手术切除根治与否。结论 肝癌术后AFP的监测和定期的CT检查是发现复发性肝癌的最佳途径。再切除是治疗复发性肝癌的有效方法之一。肿瘤的大小、数目、复发时间。

Objective To evaluate the diagnostic approaches and influencing factors of prognosis after repeated hepatectomy for recurrent liver cancer. Methods Fifty seven cases of recurrent liver cancer underwent surgical resection. The disease free survival, cumulative survival and possible influencing factors of prognosis were studied. Results The 1-, 3-, 5- and 10-year disease free survival rates after first resection were 63.9%, 38.3%, 26.6% and 12.8%, respectively. The 1-, 3-, 5- and 10-year survival rates of resection for recurrent liver cancer were 56.6%, 37.7%, 31.9% and 16.2% and the 1-, 3-, 5- and 10-year cumulative survival rates were 82.1%, 60.85, 47.6% and 19.5%, respectively. The influencing factors of prognosis after repeated hepatectomy for recurrent liver cancer size, number of nodules, tumor-free duration and weather when the patients underwent curative resection. Conclusions For early detection of recurrent liver cancer, AFP test, sonography each month and computed tomography every 3 months should be conducted for patients after the first hepatectomy. For the recurrent liver cancer, surgical resection is an effective treating measure when it is possible. The influencing factors of prognosis after repeated hepatectomy for recurrent liver cancer are tumor size, number of nodules, tumor-free duration, tumor capsule and manner of repeated hepatectomy.