先天性胰胆管合流异常与胆囊癌的关系

Relationship between gallbladder carcinoma and anomalous arrangement of pancreaticobiliary ductal system

目的 从细胞增殖活性的角度了解胰胆管合流异常 (AAPB)和胆囊癌的关系。方法 ABC免疫组化法。结果 增殖细胞核抗原 (PCNA)和单克隆抗体Ki 6 7阳性细胞在AAPB合并胆囊癌的非癌部 (B组 )为 (9 2± 3 8) % ,高于不伴AAPB的胆囊癌非癌部 [D组 ,(6 6± 5 ) % ],明显高于单纯的慢性胆囊炎组 [E组 ,(1 8± 1 0 % ) ];另外 ,不伴有其他胆道疾患的AAPB(C组 )的上皮细胞增殖率[(7 4± 2 7) % ],也明显高于单纯的慢性胆囊炎组。结论 胆囊上皮细胞增殖活性在有AAPB时明显高于无AAPB者 ,此与慢性胆囊炎的存在无关。这一增殖活性的增高可能与上皮恶性变密切相关 。

Objective To investigate the relationship between gallbladder carcinoma (GBC) and anomalous arrangement of pancreaticobiliary ductal system (AAPB) through studying the proliferation of gallbladder epithelial cells. Methods ABC Immunohistochemical staining was employed. Results Ki 67 And proliferating cell nuclear antigen PCNA labeling indexes of the non cancerous mucosa in the patients with AAPB and GBC were significantly higher than those in patients with GBC alone (P<0.05). Both of the 2 indexes were significantly higher in patients with AAPB alone than in those with cholecystolithiasis alone and the controls (P<0.01). Conclusions Cell proliferation of gallbladder epithelium is accelerated in patients with AAPB. Therefore, AAPB is an important risk factor for the occurrence of GBC.