子宫内膜癌患者血清人附睾蛋白4、人软骨糖蛋白-39水平的变化及其临床意义

Changes and clinical significance of serum levels of HE4 and YKL 40 in patients with endometrial carcinoma

目的探讨血清人附睾蛋白4（HE4）、人软骨糖蛋白-39（YKL40）水平在子宫内膜癌患者中的变化及临床意义。方法应用酶联免疫吸附法检测60例子宫内膜癌、57例子宫内膜增生患者血清HE4、YKL-40水平，并以60例健康体检者作对照。结果子宫内膜癌组血清HE4、YKL-40水平分别为（214．75±35．36）μmol／L，（99．16±21．39）μg／L，显著高于子宫内膜增生组的（54．23±11．46）μmol／L，（40．58±9．63）μg／L，差异有统计学意义（t=32．88，18．31，均P〈0．05）；而子宫内膜增生组和健康组之间差异无统计学意义（t=3．17，1．98，均P〉0．05）；相关性分析表明，HE4与YKL-40表达呈显著正相关（r=0．715，均P〈0．01）。结论HE4、YKL-40可作为子宫内膜癌血清学标志物，在子宫内膜癌中的过度表达可能与其发生和发展有关，为判断子宫内膜癌的早期辅助诊断、疗效评估的重要指标之一。

Objective To explore the changes and clinical significance of serum levels of HFA and YKL-40 in patients with endometrial carcinoma. Methods The serum levels of HFA and YKL-40 were detected by ELISA in 60 patients with endometrial carcinoma and 57 patients with endometrial hyperplasia. 60 healthy people were selected as the control group. Results The serum levels of HFA and YKL-40 in the endometrial carcinoma group were [ （214. 75 ± 35.36）μmol/L, （99.16 ±21.39） μg/L] respectively,which were significantly higher than [ （54.23 ± 11.46） μmol/L, （40.58 ± 9.63 ）μg/L ] in the endometrial hyperplasia group （ t = 32.88,18.31, all P 〈 O. 05 ）, while the serum levels of HFA and YKL-40 between the endometrial hyperplasia group and the control group were not signif- icantly different（ t = 3.17,1.98, all P 〉 0.05 ）＋. The results of correlation analysis showed that the HFA level was posi- tively correlated with the YKL-40 level （ r = 0.715 ,P 〈 0. O1 ）. Conclusion Serum levels of t-IFA and YKL-40 can be seen as serology markers of the endometrial carcinoma. The overexpression of HFA and YKL40 in endometrial car- cinoma indicates that may be related to endometrial carcinoma carcinogenesis and development, which can be impor- tant index for assessment of early diagnosis, therapeutic efficacy.