用作药物载体的氧化石墨烯包裹SiO_2微球的制备

Synthesis of the silica@graphene oxide microspheres with core-shell structure as drug carriers

在经氨基修饰的SiO2微球表面包裹氧化石墨烯,制备核壳结构的SiO2-NH2@GO复合微球。采用傅立叶转换-红外光谱仪(FT-IR)、扫描电子显微镜(SEM)、透射电子显微镜(TEM)和紫外分光光度计(UV)等对样品进行表征与分析。结果表明,SiO2-NH2@GO复合微球具有良好的单分散性(粒径约为550nm),并且GO均匀地包裹在SiO2表面。与纯SiO2相比,SiO2-NH2@GO通过布洛芬溶液浸泡载药的载药率有了较大提高,从42.9%提高到了68.8%,并且表现出更好的缓释性,24h累积释药量达到92%,给药时间延长20h左右。表明SiO2-NH2@GO复合微球有望成为一种新的药物载体。

The silica@graphene oxide （SiO2-NH2@GO）microspheres with core-shell structure were synthesized through the electrostatic interactions by encapsulation of graphene oxide on the surface of amino modified silica microspheres.The as-prepared microspheres were characterized by FT-IR,SEM,TEM and UV,etc.The re-sults show that the SiO2-NH2@GO microspheres are monodispersed with the diameter of 550 nm.GO wrapped on SiO2 surface evenly which were examined by SEM and TEM.Compared with pure SiO2 ,the drug loading of SiO2-NH2@GO microspheres was increased highly from 42.9% to 68.8% after immersed in ibuprofen solu-tion,the 92% drug was released after soaked for 24 h and the administration time was prolonged about 20 h. This implies that the monodispersed SiO2-NH2@GO microspheres synthesized in this work have potential usage as drug carriers in the biomedical fields.