摘要
目的:建立洛伐他汀片溶出度检测的新方法。方法:桨法,以0.5％十二烷基硫酸钠的磷酸二氢钠溶液为溶剂,采用紫外分光光度法测定,检测波长238nm。结果:线性范围2～14μg·ml^(-1),r=1.0000,回收率99.8％,RSD=0.2％。结论:方法简便,结果准确,可作为该品种溶出度测定的检测方法。
Objective: To establish a UV method for the dissolution determination of lovastatin tablet. Method: Paddle apparatus, 0.5% sodium dihydrogen phosphate solution of sodium dodecy sulphate was used as solvent. UV spectrophotometry was used in detemination at 238 nm. Results: The linear range was from 2 to 14 μg·ml-1 ( r=1. 000 0) . The recovery was 99. 8% , RSD was 0. 22% . Conclntion: The method was proved to be simple, accurate in the dissolution determination of lovastatin tablet.
出处
《中国药师》
CAS
2000年第6期338-339,共1页
China Pharmacist
