GM-CSF对化疗后白细胞减少的疗效观察

Therapeutic Effect of GM-CSF for Patients After Chemotherapy with Leucopenia

目的:观察粒-巨噬细胞集落刺激因子(Gm-CSF)治疗化疗所致Ⅲ～Ⅳ度白细胞减少的疗效。方法:Ⅲ～Ⅳ度骨髓抑制癌症病人,分别ih生白能150μg·d^(-1)连用5～7d及150～300μg·d^(-1)连用8～10d。结果:用药3～5d外周血白细胞计数开始回升,3～14d恢复正常。结论:GM-CSF能促进骨髓功能恢复,减少感染并发症。

Objective: To determine the therapeutic effect of granulocythe-macrophage clone stimulatie factor(GM-CSF) in the treatment of patients with Ⅲ-Ⅳleucopenia induced after chemotherapy. Methods: Patients with cancer and with bone marrow depression Ⅲ-Ⅳreceived subcutaneously leucomax 150 ng'd'1 for 5-7 days or 150-300 μg·2d-1 for 8-10 days, respectively. Results: The peripheral WBC rose at injected for 3-5 days, and returned to normal after 3-14 days. Conclusion; The GM-CSF could promote the resume of bone marrow function, and reduced the infectious complication.