IGF-1在宫颈鳞状细胞癌中的表达及预后分析

Expression of IGF-1 in cervical squamous cell carcinoma and its relationship with prognosis

目的:探讨胰岛素样生长因子-1(insulin-like growth factor-1,IGF-1)在宫颈鳞状细胞癌组织中的表达、临床病理意义及其与预后的关系。方法:应用免疫组织化学EnVisionTM法分别检测慢性宫颈炎30例、宫颈上皮内瘤变35例及宫颈鳞状细胞癌75例组织中IGF-1的表达情况。结果:IGF-1表达阳性率在慢性宫颈炎组织中为3.33%,宫颈上皮内瘤变组织中为37.14%,宫颈鳞状细胞癌组织中为57.33%,3组之间差异有统计学意义(χ2=26.13,P<0.01)。在宫颈鳞状细胞癌相关临床病理因素中,IGF-1的表达与肿瘤大小、淋巴结转移、远处脏器转移、FIGO分期有关,差异均有统计学意义(均P<0.05);但与年龄、组织学类型、增值指数(Ki-67)、P53无关,差异无统计学意义(P>0.05)。生存分析显示,IGF-1蛋白阳性患者生存率明显低于阴性患者,差异有统计学意义(χ2=4.42,P<0.05)。结论:在不同的宫颈病变中,IGF-1的表达随着病变的升级而逐步升高,这表明IGF-1在一定程度上参与了宫颈病变的演变,同时也预示着患者预后差。

Objective：To investigate the expression of insulin-like growth factor-1（ IGF-1） in cervical squamous cell carcinoma and its clinicopathological significance and the relationship between prognosis and the expression of IGF-1. Methods： The expression of IGF-1 was detected by immunohistochemisty（ EnVisionTM）in 30 cases with chronic cervicitis,35 cases with cervical intraepithelial neoplasia and 75 cases with cervical squamous cell carcinoma. Results： The expression rate of IGF-1 protein in chronic cervicitis,cervical intraepithelial neoplasia and cervical squamous cell carcinoma was 3. 33%,37. 14%,57. 33%,respectively,there was statistically significant among them（χ2= 26. 13,P 0. 01）. In cervical squamous cell carcinoma related clinical pathology factors,the expression of IGF-1was related to tumor size,lymph node metastasis,distant place organ metastasis and FIGO Staging（P 0. 05）,but not to age,histological type,Ki-67 and P53（ P 0. 05）. Survival analysis showed that the survival rate of positive IGF-1 was obviously less than negative IGF-1（χ2= 4. 42,P 0. 05）. Conclusion：In cervix morbid change,the expression of IGF-1 is escalated along with morbid change upgrade,which indicated that IGF-1 took part in the development of cervix morbid change,meanwhile,the patients prognosis is poor.