激素联合丙种球蛋白治疗小儿重症肌无力的疗效及对患儿免疫球蛋白和补体的影响

The Clinical Effect of Gamma Globulin Combined with Hormone in Treatment of Children with Myasthenia Gravis and its Effect on Immune Globulin and Complement

目的:探讨激素联合丙种球蛋白治疗小儿重症肌无力的临床疗效及对患儿免疫球蛋白和补体的影响。方法:回顾性分析在我院治疗的70例重症肌无力患儿的临床资料,采用随机序号的方式将其分为观察组和对照组各35例,观察组给予甲泼尼龙联合丙种球蛋白,对照组仅给予甲泼尼龙,观察两组的临床疗效及免疫球蛋白和补体变化情况。结果:观察组总有效率为94.3%明显优于对照组74.3%,两组比较有统计学意义(P<0.05);观察组症状明显缓解时间(6.55±1.35)d以及总住院天数(17.15±3.65)d较对照组明显缩短,两组比较差异均有统计学意义(P<0.05)。结论:采用激素联合丙种球蛋白治疗小儿重症肌无力,可以明显改善患者肌无力症状,获得较为满意的临床疗效,值得进一步推广使用。

Objective： To investigate the clinical effect of Gamma globulin combined with hormone in treatment of children with myasthenia gravis and its effect on immune globulin and complement. Methods： The clinical data of 70 children in our hospital patients with myasthenia gravis were retrospectively analyzed. By random number approach, they were divided into observation group and control group, and each group had 35 cases, children in the observation group were given methylprednisolone combined gamma globulin while those in the control group was only received methylprednisolone. The clinical efficacy and immune globulin and complement changes were compared between the two groups. Results： The total effective rate of the observation group was 94.3% significantly better than 74.3% of the control group, there was statistically significant （P〈0.05）; symptoms remission time of the observation group were （6.55 ± 1.35） d, and the total hospital days were （17.15 ± 3.65） d significantly shorter than the control group, the difference was statistically significant （P〈0.05）. Conclusion： The gamma globulin combined with hormone in treatment of children with myasthenia gravis can significantly improve symptoms with myasthenia gravis, and a more satisfactory clinical outcome was obtained, thus the treatment is worth to be further promoted in clinical.