瑞芬太尼复合七氟醚在颅内动脉瘤栓塞术中的临床观察

The Clinical Observation of Remifentanil Combined with Sevoflurane in Intracranial Aneurysm Embolization

目的:探讨瑞芬太尼复合七氟醚在颅内动脉瘤栓塞术中的临床效果。方法:回顾性分析在我院行择期颅脑动脉瘤栓塞术的70例患者的临床资料,按照随机序号的方式将其分为观察组和对照组各35例,观察组患者采用瑞芬太尼复合七氟醚麻醉,对照组采用瑞芬太尼复合异丙酚麻醉,对两组麻醉诱导前1 min(T1)、麻醉诱导后1 min(T2)、插管时(T3)、手术开始后30 min(T4)以及拔管时(T5)患者的血压、心率变化及清醒后拔管时间进行记录和分析。结果:两组患者在T2时收缩压(Systolic blood pressure,SBP)、舒张压(Diastolic blood pressure,DBP)和心率(Heart Rate,HR)均较T1明显下降,比较差异均有统计学意义(P<0.05);观察组患者的清醒时间(5.1±1.5)min及拔管时间(15.5±7.5)min均明显短于对照组,两组比较差异有统计学意义(P<0.05)。结论:在进行颅内动脉瘤栓塞术时,选择使用瑞芬太尼复合七氟醚的麻醉方式,可使患者血流动力学较为稳定,术后苏醒较快,值得在临床推广应用。

Objective： To investigate the clinical effectofremifentanil sevofluraneinintracranial aneurysm embolization. Methods： The clinical data of 70 patients with intracranial aneurysm embolization in our hospital were retrospective analyzed. According to the random number approach, they were divided into observation group and control group, 35 cases in each group. The observation group was treated with remifentanil and sevoflurane anesthesia while the control group was used with remifentanil and propofol anesthesia. The patients＇ blood pressure, heart rate and waking extubation time were recorded and analyzed lmin before anesthesia induction （T1）, lmin after anesthesia induction （T2）, intubation （T3）, 30 rain after surgery start （T4） and extubation （T5）. Results： The SBP, DBP and HR in T2 had decreased significantly compared with those in T1, and the differences were statistically significant （P〈0.05）; the waking time were （5.1 ± 1.5） min and extubation time were （15.5± 7.5） min in the observation group were significantly shorter than those in the control group, the difference was statistically significant （P〈0.05）. Conclusion： During intracranial aneurysm embolization, the patients hemodynamie were stable by using of remifentanil and sevoflurane anesthesia, and it has a rapid postoperative recovery, which is worth to be applied in clinical.