轮状病毒肠炎患儿的临床表现与肠道外多脏器损伤的相关性

The Relationship Between Clinical Manifestations with Parenteral Organs Lesion in Infant with Rotavirus Enteritis

目的：探讨轮状病毒（RV）肠炎患儿的在腹泻、呕吐、发热及脱水程度等临床表现与肠外多脏器损伤的相关性。方法：选取2009年1月-2012年6月在我院儿科住院治疗的轮状病毒肠炎患儿193例，留取其大便、尿液及血液，以便进行大便常规、肠道细菌培养、RV抗原检查、尿常规、血常规以及生化指标检测，所有患儿行胸部X线、心电图等常规检查，并根据诊断标准判断其肠外脏器损伤情况。结果：193例RV肠炎患儿中有呼吸系统损伤120例，占62．17％，心肌损伤82例，占42．49％，肝脏损伤63例，占32．64％，肾脏损伤22例，占11．40％，神经系统损伤15例，占7．77％；呕吐持续≥3d与呼吸系统损伤、肾脏损伤及神经系统损伤有相关性，差异有统计学意义（P〈0．05）；腹泻≥10次／d与呼吸系统损伤有相关性，差异有统计学意义（P〈0．05）；发热持续≥3d及中重度脱水与心肌损伤、肝脏损伤、肾脏损伤及神经损伤有相关性，差异有统计学意义（P（0．05）。结论：RV肠炎患儿临床表现严重程度与肠外脏器损伤存在一定的相关性。

Objective： To analyze the relationship of clinical manifestations （such as diarrhea, vomit, pyrexia, dehydration） with parenteral organs lesion in infant with rotavirus enteritis. Methods： 193 cases of infant with rotavirus enteritis in pediatrics from January 2009 to June 2012 were selected and their stool, urine and blood were collected for stool routine inspection, intestinal bacteria cultivation, the RV antigen examination, routine urine and blood tests and biochemical indicator detection. All the cases took the chest X-ray, ECG and other routine inspections. Their parenteral organs lesions were judged according to the diagnostic criteria. Results： In 193 cases of the RV enteritis, there were 120 cases with respiratory system injury （62.17%）, 82 cases with myocardial injury （42.49%）, 63 cases with liver damage （32.64%）, 22 cases with kidney damage （11.40%）, 15 cases with nervous system damage （7.77%）; Vomiting over 3 d had a correlation with respiratory damage, kidney damage and nerve system damage （P〈0.05）; Diarrhea over 10 times every day had a correlation with respiratory darnage（P〈0.05）; Fever over 3 d and moderate and severe dehydration had correlations with heart, liver, kidney and nervous system damage （P〈0.05）. Conclusion： The severity of clinical manifestations in infant with rotavirus enteritis has a certain correlation with parenteral organs lesion.