摘要
目的观察养肺消疹汤治疗表皮生长因子受体酪氨酸激酶抑制剂(EGFR-TKIs)药物相关不良皮肤反应的疗效。方法将50例服用EGFR-TKIs后出现皮疹的非小细胞肺癌患者随机分为2组各25例,治疗组采用养肺消疹汤口服联合外洗进行治疗,对照组采用吡美莫司软膏外用的方法进行治疗,观察各组皮疹分级、中医证候、生活质量改善情况。结果治疗组在各个检测时点皮疹分级均有显著改善,且优于对照组;治疗30 d后治疗组、对照组皮疹治疗有效率分别为72%与44%;治疗前后治疗组与对照组中医证候改善率分别为92%与36%;治疗14,30 d后2组生活质量评分治疗组有显著优势。结论养肺消疹汤口服联合外洗对EGFRTKIs药物相关不良皮肤反应具有良好疗效。
Objective To observe the curative effect of Yangfei Xiaozhen Tang on EGFR-TKIs-related adverse skin reactions.MethodsThe patients(n=50) with non-small-cell lung cancer(NSCLC) and rash after taking EGFR-TKIs were randomly divided into two groups and respectively treated with Yangfei Xiaozhen Tang used orally combining washing(treatment group,n=25) and external pimecrolimus ointment(control group,n=25).The changes of rash grading,TCM syndromes and relief of quality of life(QOL) were observed in two groups.Results In treatment group,the rash grading was improved at all time points.After treatment for 30 days,the effective rate was 72% in treatment group and 44% in control group.The recovery rate of TCM syndromes was 92% in treatment group and 36% in control group after treatment.The scores of QOL were superior in treatment group after treatment for 14 days and 30 days.ConclusionYangfei Xiaozhen Tang used orally combining washing has good curative effect on EGFR-TKIs-related adverse skin reactions.
出处
《北京中医药大学学报(中医临床版)》
2013年第6期17-19,共3页
Journal of Beijing University of Traditional Chinese Medicine