不孕症患者下生殖道支原体感染与血清抗精子抗体相关性分析

Correlation between lower genital tract mycoplasma infection and serum antisperm antibodies in infertile women

目的:研究女性不孕症患者下生殖道解脲支原体(UU)感染与血清抗精子抗体阳性之间的关系。方法:2011年3月至2012年3月就诊的120例女性不孕症患者为观察组,纳入同期健康体检的60例有生育史的女性为对照组。采用培养法对受试者宫颈黏液进行UU检测,酶联免疫吸附法检测血清抗精子抗体(AsAb)。结果:观察组UU阳性检出率(55.8%)明显高于对照组(23.3%,χ2=17.071,P<0.05);观察组AsAb阳性率(45%)明显高于对照组(10%,χ2=22.050,P<0.05);UU检测阳性患者AsAb阳性率(60.5%)明显高于UU阴性患者(11.1%,χ2=48.889,P<0.05)。结论:下生殖道UU感染及血清AsAb阳性是导致女性不孕症的重要原因,AsAb的产生与UU感染有关。

Objectives： To explore the correlation between lower genital tract itffection of ureaplasma urealyticum （UU） and serum antisperm antibodies in infertile women. Method： The observation group included 120 infertile female patients who came to our hospital from March 2011 to March 2012. The control group included 60 healthy women with reproductive history who received physical examination in our hospital during the same period. UU was detected by cultivation of cervical mucus, and en- zyme -linked immunosorbent assay was used for the detection of serum antisperm antibody （AsAb）. Results： The UU positive rate in the observation group was significantly higher than that in the control group （55.8% vs. 23.3%, X2 = 17. 071, P 〈0. 05）. The AsAb positive rate in the observation group was significantly higher than that in the control group （45% vs. 10%, X2 =22. 050, P 〈0.05）. The AsAb positive rate of patients with UU infection was significantly higher than that of UU negative patients （60.5% vs. 11.1%, X2 = 48. 889,P 〈 0. 05）. Conclusion： Lower genital tract infection of UU and serum As Ab positive were important causes of female infertility. AsAb positive is related with UU infection.