加味酸枣仁汤治疗阴虚体质失眠症44例临床观察

Clinical observation on the therapeutic effect of treating Yin-deficient people with insomnia with Suan Zao Ren decoction:44 cases

目的:探讨加味酸枣仁汤治疗阴虚体质失眠患者的治疗效果。方法:选取2012年8月至2013年2月在我院治未病中心门诊进行诊治的的88例阴虚体质失眠症患者作为研究对象,并随机分为治疗组和对照组,每组各44例。治疗组患者采用加味酸枣仁汤进行治疗,每日1剂,共150 mL,分早晚2次顿服;对照组采用口服阿普唑仑治疗,每次0.4 g,睡前服用。2组均以14 d为1个疗程,1个疗程结束后采用SPIEFEL睡眠量表评定治疗效果。结果:治疗组治愈22例,显效11例,有效9例,无效5例;对照组治愈11例,显效9例,有效12例,无效12例。治疗组总有效率88.89%,对照组总有效率72.09%,2组间比较差异有统计学意义(P<0.01)。治疗组平均药物起效时间为8.3±2.5 d,对照组平均药物起效时间为3.6±1.3 d,对照组药物起效时间明显优于治疗组,差异有统计学意义(P<0.05)。治疗组患者未出现明显不良反应,对照组患者出现1例耐药反应,2例晨起宿醉反应,3例胃肠道反应,不良反应发生率为13.6%。对照组不良反应发生率明显高于对照组,差异有统计学意义(P<0.01)。结论:加味酸枣仁汤针对阴虚体质失眠患者有显著疗效,且无明显不良反应,临床上值得推广应用。

Objective： To observe the effect of using Suan Zao Ren decoction to treat Yin-deficient people with insomnia. Methods： select 88 cases of Yin-deficient outpatients with insomnia who diagnosed in Preventive Treatment of Disease ambulatory in our hospital, and randomly divided them into the treatment group （44 cases） and control group （44cases）. The treatment group were given Suan Zao Ren decoction 150 ml per day, taken early morning and before sleep orally; the control group were given alprazolam 0. 4g per day orally, taken before sleep. For all the patients, the treatment were last for ld days. SPIEFEL sleepiness scores was used to evaluate the clinical therapeutic effect. Results： In treatment group, 22 patients were healed, 11 patients were greatly improved, 9 patients were slightly improved, and 5 patients were not improved; in control group, 11 patients were healed, 9 patients were greatly improved, 12 patients were slightly improved, and 12 patients were not improved. The total effective rate in the treatment group was 88.89% , much higher than 72. 09% in control group, which have a statistically significant（P 〈 0.01 ）. The average drug onset time in treatment group was 8.3 ± 2.5 days, longer than 3.6 ±1. 3 days in the control group, and it have a statistically significant （ P 〈 0.05）. In the control group, 1 patient had drug resistance, 2 patients had hangover reaction, and 3 patients had advocacy reaction, while the treatment group showed no apparent adverse reactions, and the adverse reaction rate in treatment group was much lower than control group,which also have a statistically significant（P 〈 0. 01 ）. Discussion ： The therapeutic effect of treating Yin-defieient people with insomnia with Suan Zao Ren decoction is much better than alprazolam, and no apparent adverse reaction was observed, these indicated Suan Zao Ren decoction is a better therapy for treating insomnia.