期刊文献+

环境污染物免疫毒性及其研究技术 被引量:4

Progress in the Technology and Research of the Immunotoxicity of Environmental Pollutants
下载PDF
导出
摘要 随着免疫毒理学的发展以及人类对免疫毒性的认识,外源物质的免疫毒性逐渐成为毒理学研究热点。国内外诸多研究表明,多数环境污染物具有免疫毒性,并且不同的污染物产生免疫毒性的作用机制也不同。论文介绍了免疫毒性的基本概念和主要研究技术,综述了这些研究技术在当前环境污染物的免疫毒性研究中的应用,并提出了免疫毒性研究发展中的不足。 With the development of immunotoxicology and the increase of awareness of immunotoxicity, re- searches on the immunotoxicity of foreign substances became more and more popular. At home and abroad, Many researches had shown that most pollutants have immunotoxicity. And the mechanisms behind these im- munotoxicity were different. This paper introduced the concept and research technology of immunotoxicity, summarized the use of these research methods in the area of environmental toxicology and raised the shortage of current immunotoxicity researches.
出处 《生态毒理学报》 CAS CSCD 北大核心 2013年第6期857-863,共7页 Asian Journal of Ecotoxicology
基金 国家自然科学基金项目(21007047) 国际科技合作计划资助(2010DFA91800) 高等学校博士学科点专项科研基金(20090072120058)资助
关键词 免疫 免疫毒性 环境污染物 淋巴细胞 immune immunotoxicity environmental pollutants lymphocyte
  • 相关文献

参考文献49

  • 1Selgrade M K. Use of immunotoxicity data in health risk assessments: Uncertainties and research to im- prove the process [J]. Toxicology, 1999, 133(1): 59 - 72.
  • 2梁春来,贾旭东.免疫毒性评价方法研究进展[J].毒理学杂志,2011,25(4):301-304. 被引量:1
  • 3EMEA/CHMP. Immunotoxicity Studies for Human Phar- maceuticals (EMEA/CHMP/167235/2004) [ R ]. London, 2005.
  • 4OECD. Organisation for Economic Coopereration and Development, OECD Guidelines for Testing of Chemi- cals [S]. No.407.1981.
  • 5齐丽娟,李宁.免疫毒理学的评价方法及其研究进展[J].国外医学(卫生学分册),2008,35(3):174-180. 被引量:15
  • 6谭壮生,赵振东.免疫毒理学[M].北京:北京大学医学出版社.2010:121.
  • 7陈慰峰.医学免疫学[M].北京:人民卫生出版社,2004.166.
  • 8Ferrante M C, Mattaee R G, Esposito E, et al. Effects of non-dioxin-like polychlorinated biphenyl congeners (PCB 101, PCB 153 and PCB 180) alone or mixed on J774A.1 macrophage cell line: Modification of apoptot- ic pathway [J]. Toxicology Letters, 2011, 202(1): 61 -68.
  • 9Boiling A K, Ovrevik J, Samuelsen J T, et al. Mono-2- ethylhexylphthalate (MEHP) induces TNF-alpha re- lease and macrophage differentiation through different signalling pathways in RAW264.7 cells [J]. Toxicology Letters, 2012, 209(1): 43 - 50.
  • 10Nunez M A, Estrada I and Calderon-Aranda E S. DDT inhits the functional activation of murine macropha- ges and decreases resistance to infection by Myco- bacterium microti [J]. Toxicology, 2002, 174(3): 201 - 210.

二级参考文献38

  • 1洪霞,郭薇,李军,刘艳梅,杨文胜,白玉白,李铁津,袁航,马岚.Fe_3O_4/葡聚糖/抗体磁性纳米生物探针的制备和层析检测[J].高等学校化学学报,2004,25(3):445-447. 被引量:31
  • 2左国华,梁平,李洪艳.肝细胞癌免疫磁珠的制备及鉴定[J].第三军医大学学报,2005,27(16):1700-1701. 被引量:6
  • 3肇静娴,曾耀英,刘毅,何贤辉.联合应用活体染料CFDA-SE和SNARF-1检测混合淋巴细胞反应[J].细胞与分子免疫学杂志,2006,22(3):382-384. 被引量:8
  • 4Descotes J. Methods of Evaluating Immunotoxicity [ J ]. Expert Opin Drug Metab Toxicol, 2006, 2 (2) : 249-259.
  • 5Descotes J (Ed.). Immunotoxicology of Drugs and Chemicals: An Experimental and Clinical Approach, Volume 1: Principles and Methods of Immunotoxieology [ M ]. 3rd ed. Elsevier Science Publishing Company, 2004.
  • 6Oshiro Y, Morris DL. TNF-α release from human peripheral blood mononuclear cells to predict the proinflammatory activity of cytokines and growth factors [J]. J Pharmacol Toxicol Methods, 1997, 37 (1) : 55- 59.
  • 7Ravel G, Descotes J. Popliteal lymph node assay: facts and perspectives [ J]. J Appl Toxicol, 2005, 25 (6) : 451- 458.
  • 8Gennari A, Ban M, Braun A, et al. The Use of In Vitro Systems for Evaluating Immunotoxicity: The Report and Recommendations of an ECVAM Workshop [ J ]. J Immunotoxicol, 2005, 2 (2): 61-83.
  • 9Carfi M, Gennari A, Malerba I, et al. In vitro tests to evaluate immunotoxicity: A preliminary study [ J ]. Toxicology, 2007, 229 : 11-22.
  • 10US Environmental Protection Agency ( EPA ). Immunotoxicogenomics Workshop[ C/OL]. RTP campus of the Environmental Protection Agency, September 27-28, 2005 [ 2010-08-25 ]. http://www, epa. gov/NHEERL/ immunogen_workshop/.

共引文献57

同被引文献27

引证文献4

二级引证文献11

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部