低分子肝素联合西地那非治疗肺切除术后肺动脉高压的疗效分析

Effects analysis of low molecular weight heparin combined with sildenafil in the treatment of pulmonary hypertension after lung resection

目的探讨低分子肝素联合西地那非治疗肺切除术后肺动脉高压的临床疗效。方法将13例肺切除术后肺动脉高压患者随机分为三组,使用西地那非(A组),使用低分子肝素(B组),联合应用上述两种方法(C组),三组患者在干预前、干预后第3天和第7天均再次测定肺动脉压力。结果应用西地那非组和低分子肝素组肺动脉压力第3天和第7天均有下降,结果有统计学意义(P<0.05)。而联合干预组肺动脉压力下降更明显,结果有统计学意义(P<0.05)。结论早期联合应用低分子肝素和西地那非对降低肺动脉压力有协同作用。

Objective To analyze the curative effects of low molecular weight heparin combined with sildenafil in the treatment of pulmonary hypertension after lung resection. Methods The patients were randomly divided imo three groups ： the use of Sildenalil （ Group A ）, the use of Low molecular weight heparin （ Group B ）, the combination of these two methods （ Group C ）, three groups of patients after intervention, interventiun before the third day and seven days are once again the determination of pulmonary artery pressure. Results Appficafion of Sildenafil puhnonary arterial pressure groups ,and Low molecular weight heparin group third and seventh days were dropped, the result was statistically significant （ P〈0.05 ）.Combined pulmonary arterial pressure drop in the intervention group more obvious, the result was statistically significant （ P〈0.05 ）. Conclusions Early combination of Low molecular weight heparin and Sildenafil on a collaborative role in reducing pulmonary arterial pressure.