3Gubin J,Lucchetti J,Inion H. Preparation of benzofurans, benzothiophenes, indoles, and indolizines as cardiovascular agents[P].EP,471609,1992.
4Fino N,Leroy C. A process for the preparation of 2-butyl-5-[methanesulfonamido] benzofuran as an intermediate for the synthesis of dronedarone[P].WO,2002048132,2002.
2Dale K M, White C M. Dronedarone: an amiodarone analog for the treatment of atrial fibrillation and atrial flutter[J]. Ann Pharmacother, 2007,41 (4): 599-605.
3Lalevee N, Nargeot J, Barrere-Lemaire S, et al. Effects of amiodarone and dronedarone on voltage-dependent sodium current in human cardiomyocytes[J]. J Cardiovasc Electrophysiol,2003,14(8): 885-890.
4Gautier P,Guillemare E, Marion A, et al. Electrophysiologic characterization of dronedarone in guinea pig ventricular cells [J]. J Cardiovasc Pharmacol,2003,41(2): 191-202.
5Chatelain P, Meysmans L, Matteazzi J R, et al. Interaction of the antiarrhythmie agents SR 33589 and amiodarone with the beta-adrenoceptor and adenylate eyclase in rat heart[J]. Br J Pharmacol, 1995,116(3) : 1949-i956.
6Sun W, Sarma J S, Singh B N. Electrophysiological effects of dronedarone ( SR33589), a noniodinated benzofuran derivative,in the rabbit heart:comparison with amiodarone[J]. Circulation, 1999,100(22) : 2276-2281.
7Sun W,Sarma J S, Singh B N. Chronic and acute effects of drone-darone on the action potential of rabbit atrial muscle preparations:comparison with amiodarone [J]. J Cardiovasc Pharmacol, 2002,39 (5) : 677-684.
8Wadhani N, Sarma J S, Singh B N, et al. Dose-dependent effects of oral dronedarone on the circadian variation of RR and QT intervals in healthy subjects: implications for antiar-rhythmic actions[J]. J Cardiovasc Pharmacol Ther, 2006,11 (3) : 184-190.
9Pantos C, Mourouzis I, Delbruyere M, et al. Effects of dronedarone and amiodarone on plasma thyroid hormones and on the basal and postischemic performance of the isolated rat heart[J]. Eur J Pharmacol,2002,444(3) :191-196.
10van Beeren H C,Jong W M, Kaptein E, et al. Dronedarone acts as a selective inhibitor of 3,5,3 truodothyronine binding to thyroid hormone receptor-alpha1: in vitro and in vivo evidence[J]. Endocrinology,2003,144(2) :552-558.