摘要
目的研究口服与灌肠联合口服给药治疗溃疡性结肠炎的临床效果,为临床该类疾病的治疗提供依据。方法将59例溃疡性结肠炎患者随机分为口服给药组(对照组,口服美沙拉嗪)和口服联合灌肠给药组(治疗组,口服美沙拉嗪+中药灌肠),比较两组患者的临床有效率,治疗前后的临床症状和肠黏膜的病变程度,并比较两组患者的不良反应。结果治疗组患者的临床有效率可达93.8%,高于对照组,差异有统计学意义(P<0.05);治疗组患者临床症状积分低于对照组,差异有统计学意义(P<0.05);治疗组患者的肠黏膜病变程度得到明显改善,差异有统计学意义(P<0.05);两组不良反应发生率相似,差异无统计学意义(P>0.05)。结论口服联合灌肠给药改善溃疡性结肠炎患者临床症状更明显,患者肠黏膜病变程度恢复更彻底,明显好于单独的口服给药,并且用药安全,无额外不良反应发生。
Objective To study the clinical efficacy of oral drugs combined with Chinese traditional medicine enema in treatment of ulcer- ative colitis and to provide the basis for treatment of this disease. Methods A total of 59 patients with ulcerative colitis during October 2007 to September 2011 were randomly divided into two groups, oral drug treatment group （ control group） and oral drug combined with enema group （ trial group）, patients in control group were treated with oral drugs and patients in trial group were given with oral drugs combined with Chinese medi- cine enema. Their clinical effects had been observed and compared. Results The total effective rate of trial group was 93.8% , and it was higher than that of control group, and their difference was statistically significant （ P 〈 0.05 ）. The grade of scores in elinical symptoms was the lowest for trial group, it was statistically significant compared with that of control group（ P 〈0.05） ; and the changes in lesions of intestinal mueosa in pa- tients of trial group were less than those of control group, and their difference was statistically significant （ P 〈 0.05 ） ; and the occurrence of side effects in these two groups was equivalent, and their difference was not significant （ P 〉 0.05 ）. Conclusion The effieacy of oral drugs combined with Chinese traditional medicine enema is more satisfactory in treatment of ulcerative colitis, and it is better than administration of oral drugs a- lone, there was no more side effects occurred.
出处
《临床和实验医学杂志》
2013年第24期1982-1984,共3页
Journal of Clinical and Experimental Medicine
