柴胡龙骨牡蛎汤治疗抑郁证的meta分析

Meta Analysis of Chaihulonggumuli Decoction Intervening Depression

目的评价柴胡龙骨牡蛎汤治疗抑郁证的有效性和安全性。方法采用文献系统评价定性研究与定量meta分析相结合的方法与技术,检索中国期刊全文数据库、维普中文期刊数据库、万方学术期刊全文数据库1990年1月至2012年12月国内20年间的相关文献,收集柴胡龙骨牡蛎汤治疗抑郁证的随机对照试验(RCTs)。结果按纳入和排除标准筛选高质量的研究论著、提取有效数据,最终纳入10篇临床随机对照试验文献(其中有4篇是关于治疗中风后抑郁证),采用RevMan 4.2软件进行meta分析,结果显示,柴胡龙骨牡蛎汤治疗抑郁证有效率优于对照组[RR=1.10,95%CI(1.04,1.17)],4篇治疗中风抑郁证的RR=1.12,95%CI(1.04,1.22)。结论 meta分析初步提示柴胡龙骨牡蛎汤治疗抑郁证有一定疗效。

Objective To evaluate the effect of Chaihulonggumuli Decoction intervening depression. Methods We searched CNKI, VIP, WanFang （ 1990 to 2012） for randomized control trials about Chaihulonggumuli Decoction intervening depression. Results Screening trials according to the inclusion and exclusion criteria and assessment the quality of included trials, the extrac- tion of effective data, 10 randomized clinical trials and their efficiency were evaluated;statistical analysis was conducted by using RevMan 4.2 software. Meta analysis showed that the efficiency of Chaihulonggumuli Decoction on depression was better than the control group [ RR =- 1.10,95% CI （ 1.04 1.17 ） ,P 〈 0.05 ] ;four trials which for depression affer stroke, RR = 1.12,95% CI （ 1. 04,1.22 ）. Conclusion The Chaihulonggumuli Decoction intervening depression was effective.