慢性阻塞性肺疾病急性加重期合并贫血的相关因素分析

Analysis of related factors of anemia with acute exacerbations in chronic obstructive pulmonary disease

目的了解COPD急性加重期(AECOPD)合并贫血的发生率,探讨其可能相关因素。方法对2012年部分住院的AECOPD患者,根据血红蛋白的水平分为贫血组和非贫血组,比较两组一般资料、血常规和血液生化的检测结果。结果贫血组患者的年龄较高,白蛋白﹑超氧化物歧化酶(SOD)﹑总铁结合力﹑转铁蛋白均显著低于非贫血组,超敏CRP高于贫血组(P均<0.05)。两组的BMI﹑住院时间﹑肺功能﹑PaO2、血清总蛋白﹑血清铁﹑不饱和铁结合力水平比较差异均无统计学意义。Logistic多元回归分析显示,年龄﹑低白蛋白水平和SOD活性下降是AECOPD患者发生贫血的独立危险因素(P均<0.05)。结论部分AECOPD患者合并贫血,这可能与氧化∕抗氧化失衡和营养不良有关。

Objective To investigate the incidence of anemia in AECOPD and its possible related factors. Methods A part of inpatients with AECOPD in 201 2 were divided into two groups according to the levels of hemoglobin,anemia group and nonanemia group. A routine blood test and serum biochemical test were performed in two groups. Results The inpatients were older in anemia group compared to the nonanemia group. There was no significant difference between two groups with the body weight index,average hospital stay,pulmonary function parameters,arterial partial pressure of oxygen,total serum protein,serum iron and unsaturated iron-binding capacity. The levels of serum albumin,superoxide dismutase,total iron binding ca-pacity and transferrin of the patients in anemia group were significantly lower than those in the nonanemia group,but hypersensitive C-reactive protein were higher than that of the nonanemia group. Age,lower levels of serum albumin and superoxide dismutase were independent risk factors for anemia in AECOPD. Conclusion Part of the patients with AECOPD were complicated by anemia,imbalance of oxidant/antioxidant and malnutri-tion maybe associated with this situation.