王氏保赤丸治疗儿童功能性消化不良临床观察

Clinical Observation on “Wangshi Baochi Pill”for Children with Functional Dyspepsia

目的:评价王氏保赤丸治疗儿童功能性消化不良(FD)的临床疗效。方法:将150例FD患儿按照2∶1比例随机分为治疗组100例和对照组50例。治疗组给予王氏保赤丸,对照组给予吗丁啉口服液,疗程为28 d。评价两组的临床疗效及主要临床症状(餐后饱胀不适、早饱、上腹痛、上腹灼热、胃纳减少、嗳气)的变化情况。结果:治疗后,治疗组和对照组的总有效率分别为83%和68%,治疗组疗效优于对照组(P<0.05)。治疗后,治疗组患儿餐后饱胀、早饱、上腹痛、胃纳减少、嗳气症状均明显减轻(P<0.05),对照组患儿餐后饱胀、早饱、胃纳减少、嗳气症状亦明显减轻(P<0.05),且治疗组患儿胃纳减少症状的改善优于对照组(P<0.05)。结论:王氏保赤丸治疗儿童FD具有较好的疗效。

Objective： To evaluate the clinical effect of ＂ Wangshi Baochi Pill＂ for children with functional dyspepsia （FD）. Methods： One hundred and fifty children with FD wm~ randomly divided into the treatment group （100 cases） and contrnl group （50 cases） according to 2 ： 1 ratio. The treatment group was treated by ＂Wangshi Baochi Pill＂ and the control group was tl^ated by domperidone oral liquid, with a course of 28 days. The changes of main clinical symptoms, such as postprandial fullness and discomfort, early satiety, epigastric pain, epigastric burning, reduction of food intake, eructation, and the clinieal effects were evaluated. Results： After treatment, the total effective rates of treatment group and control group were 83% and 68% respectively, and the effect of treatment group was better than that of the control group （P 〈 0.05）. After treatment, the symptoms of postprandial fullness, early satiety, epigastric pain, reduction of food intake and eructation were significantly alleviated in treatment group （P 〈 0.05 ）, the symptoms of postprandial fullness, early satiety, reduction of food intake and eructation were significantly relieved in control group （ P ~0.05 ）, and the improvement of the reduction of food intake in treatment group was better than that in control group （P 〈0.05 ）. Conclusion： ＂ Wangshi Baochi Pill＂ has good effect in the treatment of FD for children.