乳腺癌患者大剂量环磷酰胺化疗方案联合G-CSF动员外周血造血干细胞

Mobilization of Peripheral Blood Stem Cells with High Dose Cyclophosphamide Combination Chemotherapy and G-CSF in Breast Cancer Patients

评价大剂量环磷酰胺化疗方案联合G CSF对乳腺癌患者外周血造血干细胞的动员效果。动员方案为在常规联合化疗方案的基础上 ,提高环磷酰胺剂量 2 - 4倍 ,化疗后当外周血WBC降至 1.0× 10 9/L以下时给予G CSF ,15 0微克 /次 ,2次 /日。在WBC恢复升高至 5 .0× 10 9/L以上时 ,进行外周血造血干细胞采集。结果共有 10例乳癌患者完成了上述方案的外周血造血干细胞动员 ,WBC降低的中位最低值为 0 .8(0 .4 - 1.0 )× 10 9/L ,造血干细胞的中位采集次数为 2 (2 - 3)次 ;采集的CD34+ 细胞中位数为 6.4 3(1.99- 18.75 )× 10 6 /kg。结论提示 ,大剂量环磷酰胺化疗方案联合G

To evaluate the effect of mobilization of peripheral blood stem cells (PBSC)with high dose cyclophosphamide combination chemotherapy and G-CSF in breast cancer patients, a new mobilization protocol was designed on the basis of standard combination chemotherapy regimen, in which the dose of cyclophosphamide was raised to 2 to 4 times, and G-CSF began to be used at the dose of 150 μg twice everyday when white blood cell (WBC)decreased below 1.0×10 9/L. PBSC collection was performed while WBC increased over 5.0×10 9/L during bone marrow recovering. The PBSC mobilization protocol was completed in 10 patients, the median nadir of WBC was 0.8(0.4-1.0)×10 9/L, the median time of PBSC collection was 2(2-4), the median number of collected CD34 + cells was 6.43(1.99-8.75)×10 6/kg. The results showed that the protocol, high dose cyclophosphamide combination chemotherapy, was an optimal PBSC mobilization regimen in breast cancer patients.