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三阴性乳腺癌的临床研究进展 被引量：2

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摘要 三阴性乳腺癌(triple-negative breast cancer,TNBC)是乳腺癌中一个具有独特病理组织学特征及临床特征的分子亚型,TNBC曾被归为基底细胞样型乳腺癌,然而两者在基因表达谱上并不完全相同。TNBC相对于其他分子亚型预后较差,辅助治疗后复发转移率较高,5年生存率低,可能与TNBC基因谱相关通路异常有关,但其对化疗较为敏感,目前治疗仍以细胞毒性化疗为主,针对EGFR等靶点的靶向治疗可能在TNBC治疗上获得较好的疗效。本文就三阴性乳腺癌的病理组织学特征以及治疗进展作一综述。
作者 肖慧敏 谢伟敏
机构地区 广西医科大学研究生学院 广西医科大学附属肿瘤医院化疗五科
出处 《中国癌症防治杂志》 CAS 2013年第4期370-373,共4页 CHINESE JOURNAL OF ONCOLOGY PREVENTION AND TREATMENT
关键词 乳腺肿瘤 三阴性乳腺癌 病理组织学特征 化疗 靶向治疗
分类号 R737.9 [医药卫生—肿瘤]
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参考文献20

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共引文献16

同被引文献26

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引证文献2

二级引证文献4

中国癌症防治杂志
2013年 第4期

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