卡托普利与开富特对高血压疗效观察被引量：2

Effective observertion of captorpril and captorpril-co on hypertension

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摘要目的研究卡托普利与开富特 (复方卡托普利 )对高血压患者的疗效及代谢的影响。方法 65例原发性高血压患者随机分为两组，第 1组：用卡托普利 25～ 75 mg，每日 2～ 3次。第 2组：开富特 (卡托普利 10 mg加氢氯噻嗪 6 mg )每日 2～ 3次，两组治疗时间均为 8周，测定治疗前、后的基础血压，空腹血糖、血脂、血钾、血尿酸、尿素氮、肌酐，以及治疗前后的 24 h动态血压。结果开富特组的总有效及 24 h动态血压结果均明显优于卡托普利组。两组治疗前后的代谢指标均无明显改变。结论开富特治疗高血压较卡托普利更有效，而且对代谢无明显影响。 Objective:To investive the influences of Captopril and Captorpril-co on effectiveness and metabolism in hypertensive patients.Methods:Sixty-five patients with essential hypertension was randomly divided into two groups.group 1:captopril of 25mg～ 75mg was used twice or three times a day;group 2:Captorpril-co(Captorpril 10mg plus hydrocholorizive 6mg) was used twice or three times a day.Treatment duration was eight weeks in each group.The basic blood pressure,fast blood glucose,blood lipid,blood potassium,bolld urinic acid,urean,blood creatine and ambulatomy blood pressure monitoring(ABPM) before,after treatment were measured.Results:The total effectiveness and the results of ABPM in group 1 and there were no significant changes of metabolism in two groups before and after treatment.Conclusion:The effectiveness of hypertension treatment with Captorpril-co is superior to that with Captorpril and has no significant influence on metabolism.

作者陈少颖惠杰

机构地区射阳县人民医院苏州医学院附一院

出处《井冈山医专学报》 2000年第4期11-12,共2页 Journal of Jinggangshan Medical College

关键词高血压卡托普利氢氯噻嗪联合用药疗效 Hypertension； Captorpril； Hydrochrolorizine

分类号 R544.105 [医药卫生—心血管疾病] R972.4 [医药卫生—药品]

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