摘要
目的研究老年２型糖尿病患者与一氧化氮等氧自由基的关系。方法检测５０例老年２型糖尿病患者（患者组）和５０例健康人（对照组）血浆一氧化氮（Ｐ－ＮＯ）、维生素Ｃ（Ｐ－ＶＣ）、维生素Ｅ（Ｐ－ＶＥ）、β－胡萝卜素（Ｐ－β－ＣＡＲ）含量及红细胞超氧化物歧化酶（Ｅ－ＳＯＤ）、过氧化氢酶（Ｅ－ＣＡＴ）、谷胱甘肽过氧化物酶（Ｅ－ＧＳＨ－ＰＸ）活性。结果与对照组比较，患者组除Ｐ－ＮＯ值显著升高（Ｐ＜０．０１）外，余各检测值均显著降低（Ｐ均＜ ０．０１）。结论老年 ２型糖尿病患者 ＮＯ代谢异常，氧化、过氧化损伤加剧。
Objective To study the correlation between nitric oxide and type 2 diabetes. Methods Detections were made on the serum levels of plasma nitric oxide, plasma vitamin C and E, carotene and erythrocyte superoxide dismutase, erythrocyte catalase, erythrocyte glutathione peroxidase in 50 type 2 diabetes cases and 50 healthy cases. Results The plasma nitric oxide level in type diabetes cases was higher that that in the healthy cases (P < 0. 01), but the levels of plasma vitamin C and E, carotene and erythrocyte superoxide dismutase, erythrocyte catalase, erythrocyte glutathione peroxidase were lower than those in the healthy cases (P < o. oi respectively). Conclusion The metabolism of nitric oxide in type 2 diabetes cases was abnormal and the oxidation, peroxidation injuries were exacerbated.
出处
《浙江临床医学》
2000年第12期799-800,共2页
Zhejiang Clinical Medical Journal
