幽门螺杆菌感染与门脉高压性胃病

Helicobacter Pylori Infection and Portal Hypertensive Gastropathy

目的探讨幽门螺杆菌（ＨＰ）感染与门脉高压性胃病（ＰＨＧ）发病之间的相关性。方法８２例门脉高压患者，内镜下参照ＭｃＣｏｒｍａｃｋ分型，分为３组：ＰＨＧ－０，缺乏ＰＨＧ表现；ＰＨＧ－Ⅰ组，轻型ＰＨＧ；ＰＨＧ－Ⅱ组，重型ＰＨＧ。同期非溃疡性消化不良（ＮＵＤ）患者３０例。快速尿素酶试验及组织学改良Ｇｉｅｍｓａ染色法检查均阳性定为ＨＰ感染。结果ＰＨＧ－０组３９例，ＨＰ感染率４６．１％，ＰＨＧ－Ⅰ组２７例，ＨＰ感染率４４．４％，ＨＰＧ－Ⅱ组１６例，ＨＰ感染率５０．０％，ＮＵＤ组ＨＰ感染率６３．３％，各组无差异（Ｐ＞０．０５）。结论ＨＰ感染在ＰＨＧ发病过程中无意义，为ＰＨＧ的非致病因素。

Objective To investigate the relationship between helicobacter pylori infection and portal hypertensive gastropathy (PHG). Methods 82 portal hypertension cases and 30 nonulcer dyspepsia (NUD) cases underwent endoscopy and the HP infection was verified by the rapid urease test and histological examination of motified Giemsa Stain. Based on the McCormack criteria, the former cases were divided into PHG- 0 group (without PGH presentations), PGH - I group (with mild presentation) and PGH - group (with severe presentations). Results HP positive infection was verified in 18 (46. 1 % ) of 39 cases of PHG - 0 group; 12 (44. 4% ) of 27 cases Of PHG - I group; 8 (50.0% ) of 16 cases of PHG - group; and 19 (63. 3% ) of NUD group were also positive for HP in- fection. No difference was found between each groups (P > 0. 05). Conclusion HP infection didn' t play a role in PHG and wasn' t a pathological factor of PHG.