丹黄通脉胶囊联合辛伐他汀片治疗颈动脉粥样硬化斑块随机平行对照研究

Danhuang Tongmai Capsule Combined with Simvastatin Tablets in Treatment of Carotid Atherosclerotic Plaque Random Parallel Controlled Study

[目的]观察丹黄通脉胶囊联合辛伐他汀治疗颈动脉粥样硬化(CAS)合并斑块疗效,评价丹黄通脉胶囊联合辛伐他汀稳定与消退斑块作用。[方法]使用随机平行对照方法,将64例门诊及住院患者按就诊顺序编号随机分为两组。对照组32例辛伐他汀10mg/次,1次/d,晚饭后服用。治疗组32例丹黄通脉胶囊,4粒/次,3次/d。西药治疗同对照组。治疗1年为1疗程。观测血脂、颈动脉内膜斑块面积、血液生化指标、不良反应。治疗1疗程,判定疗效。[结果]两组TC及TG均明显下降(P<0.05),LDL-C有所下降(P<0.05),HDL-C有所升高(P>0.05),治疗组优于对照组(P<0.05)。两组后颈动脉内膜斑块平均面积明显减小(P<0.01),治疗组优于对照组(P<0.05)。[结论]丹黄通脉胶囊联合辛伐他汀治疗CAS合并斑块疗效好、且不良反应较少。

[ Objective ] to observe the Danhuang Tongmai Capsule Combined with simvastatin in treatment of carotid atherosclerosis （ CAS ） and plaque effect. Evaluation of Danhuang Tongmai Capsule Combined with simvastatin stabilization and regression of atherosclerotic plaque. [ Method ~ using randomized controlled methods, 64 cases of outpatient and inpatient patients according to the order number were randomly divided into two groups. 32 cases of the control group simvastatin 10mg/, 1 /d, after dinner to take. The treatment group of 32 cases of Danhuang Tongmai capsule, 4 capsules each time, 3 times/d. Western medicine treatment with the control group. For 1 consecutive years to 1 course of treatment. Observation of blood lipid, carotid artery plaque area, blood biochemical index, adverse reaction. 1 courses of treatment, the curative effect. [ Result ] two groups of TC and TG decreased significantly （ P〈0.05 ）, LDL-C decreased （P〈0.05）, HDL-C increased （ P〈0.05 ）, The treatment group than the control group （ P〈 0.05 ） . The average area of two groups of carotid plaque was significantly reduced （ P〈0.01 ）, The treatment group than the control group （ P〈0.05 ） . [ Conclusion ] Danhuang Tongmai Capsule Combined with simvastatin in the treatment of CAS with good efficacy and less adverse reactions, plaque.