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益阴化瘀汤联合西药对早期糖尿病肾病微量白蛋白尿、超敏C反应蛋白影响随机平行对照研究

Random Parallel Control Study on Influence of Yiyin Huayu Decoction Combined with Western Medicine Treating Early Diabetic Nephropathy on Microalbuminuria and High-sensitive C-reactive Protein
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摘要 [目的]观察益阴化瘀汤联合西药对早期糖尿病肾病微量白蛋白尿、超敏C反应蛋白影响。[方法]使用随机平行对照方法,将90例门诊患者按随机数字表法分为两组。对照组45例口服降糖药物或皮下胰岛素注射控制血糖;控制血压(ACEI或ARB类药物首选)、纠正脂代谢紊乱、预防和防止感染;优质低蛋白饮食,避免肾毒性药物。治疗组45例益阴化瘀汤(生山药15g,党参、生地、玄参、天花粉各10g,赤芍12g,川芎、桃仁各6g,枸杞子12g,山萸肉10g),1剂/d,水煎500mL,早晚口服;西药治疗同对照组。连续治疗8周为1疗程。观测临床症状、24h尿微量白蛋白排泄率(UAER)、超敏C反应蛋白(hs-CRP)水平、不良反应。治疗1疗程,判定疗效。[结果]治疗组显效19例,有效23例,无效3例,总有效率93.30%。对照组显效12例,有效22例,无效11例,总有效率75.60%。治疗组疗效优于对照组(P<0.01)。UAER及hs-CRP水平治疗组改善优于对照组(P<0.01)。[结论]益阴化瘀汤联合西药治疗早期糖尿病肾病,疗效满意,无副作用,值得推广。 [ Objective ] To observe the influence of Yiyin Huayu decoction combined with western medicine treating early diabetic nephropathy on mieroalbuminuria and high-sensitive c-reactive protein. [ Methods ] 90 outpatients were selected and divided into two groups randomly. The control group for 45 cases were treated with antidiabetics or subcutaneous insulin injection to control blood sugar for avoiding hypoglycemia. Effective measures were effectively taken to control blood pressure ( ACEI or AttB priority drug ), to correct the lipid metabolism disorders and to prevent infection. The patients were given high-quality low-protein diet to avoid nephrotoxic drug. The treatment group for 45 cases were treated with Yiyin Huayu decoction ( 15g of Chinese Yam Juliennes, 10g of codonopsis pilosula, virgin soil and radix trichosanthis, 12g of red paeony root, 6g of ligusticum wallichii and peach seed, 12g of the fruit of Chinese wolfberry and 10g of fructus corni ), 1 dose/d. And the medicine was decoeted with water for 500 mL. The western medicine treatment is the same to the control group, and 8 weeks for treatment was one course. The clinical symptoms, 24h UAEtl, hs-CRP level and adverse reactions were observed. The efficacy after treating for 1 course was compared. [ Results ] For the treatment group, there were 19 evidently effective cases. 23 effective cases, 3 inefficient cases, and the total effective rate was 93.30%. For the control group, there were 12 evidently effective cases. 22 effective eases, 11 inefficient cases, and the total effective rate was 75.60%. The efficacy of the treatment group was better than that of the control group ( P〈0.01 ) . UAER and hs-CRP level of the treatment group was better than that of the control group ( P〈0.01 ) . [ Conclusion ] Yiyin Huayu Decoction combined with western medicine treating early diabetic nephropathy has satisfied efficacy and has no side effect, which is worthy of promotion and application.
作者 陈刚
出处 《实用中医内科杂志》 2013年第7期112-114,共3页 Journal of Practical Traditional Chinese Internal Medicine
关键词 早期糖尿病肾病 益阴化瘀汤 微量白蛋白尿 超敏C反应蛋白 中西医结合治疗 随机平行对照研究 Early diabetic nephropathy Yiyin Huayu decoction Microalbuminuria High-sensitivec-reactive protein Integrative Chinese and western medicine Random parallel control study
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