IgA肾病患者的扁桃体免疫组织化学观察

Immunohistological observation of tonsillae in IgA nephropathy

目的 :了解 Ig A肾病 (Ig A - N )与扁桃体免疫异常的关系。方法 :经肾穿刺活检确诊为 Ig A - N 31例 ,以慢性扁桃体炎 16例作对照。扁桃体切除术后运用 ABC方法对扁桃体组织进行免疫组化标记。结果 :两组扁桃体在 Ig A、Ig G的表达上存在明显的区别 ,Ig A- N患者的扁桃体组织内产生 Ig A的淋巴细胞数显著增加。结论 :Ig A-N患者存在着扁桃体免疫异常 ,切除扁桃体可预防抗原入侵 ,消除扁桃体来源的 Ig A,减少循环中的 Ig A免疫复合物形成 ,进一步使肾小球基底膜区的 Ig A免疫复合物沉积减少。

Objective:To realize the relationship between IgA nephropathy (IgA N) and immunological abnormality of tonsillae.Method:Thirty one patients were diagnosed as IgA N via renal puncture.Sixteen patients suffering from chronic tonsillitis as control. All resected tonsillae were labelled immunohistologically by ABC method.Result:The differences of expression of IgA,IgG in the tonsillae between above two groups were significantly obvious.The number of lymphocytes which can produce IgA increased in IgA N tonsillae.Conclusion:The immune functions are abnormal in IgA N patients. Tonsillectomy can prevent the antigen invasion,eliminate IgA originated from tonsillae,decrease the IgA immunocomplex in circulation,therefore decrease the IgA immunocomplex deposition in the basal membrane of glomeruli.