健脾清化散瘀饮治疗隆起糜烂性胃炎的疗效观察

Efficacy of Jianpi Qinghua Sanyu Decoction in raised erosive gastritis

[目的]观察健脾清化散瘀饮口服治疗隆起糜烂性胃炎(raised erosive gastritis,REG)的疗效。[方法]选择REG患者80例,随机分为中药组和西药组,各40例。中药组予内服健脾清化散瘀饮,西药组予兰索拉唑及复方谷氨酰胺颗粒进行治疗,疗程均为3个月;2组患者幽门螺杆菌(Hp)阳性者,均予兰索拉唑、胶体果胶铋、克拉霉素及呋喃唑酮四联抗Hp治疗。比较2组患者治疗前后临床症状、胃镜疗效、病理变化、Hp根除率及不良反应。[结果]①临床症状:2组均能改善患者主要临床症状,其中对腹痛、腹胀的疗效,2组差异无统计学意义(P>0.05),而对反酸的疗效,西药组优于中药组(P<0.05)。②胃镜疗效:中药组治愈率67.5%,总有效率82.5%;西药组治愈率45.0%,总有效率75.0%。2组治愈率相比,中药组优于西药组(P<0.05),总有效率相比,2组差异无统计学意义(P>0.05)。③病理变化:中药组治愈率优于西药组(P<0.05),总有效率差异无统计学意义(P>0.05)。④2组患者治疗前Hp感染率与治疗后Hp根除率相比,差异均无统计学意义(P>0.05)。⑤不良反应:有4例患者抗Hp治疗期间出现不良反应。服用中药期间均未出现不良反应。[结论]口服健脾清化散瘀饮治疗REG,胃镜下以及病理检查治愈率均优于西药,且未见不良反应。疗效确切、安全、可靠。

[Objective]To observe the effect of Jianpi Qinghua Sanyu Decoction on raised erosive gastritis （REG）. i-Methods^Eighty patients who were diagnosed as REG were randomly divided into traditional Chinese medicine group and western medicine group, and treated with Jianpi Qinghua Sanyu Decoction and Lansoprazole and Compound Glutamine Granules respectively for 3 months＇s Hp-positive patients in both groups were treated by Lansoprazole, Colloidal Bismuth Pectin, Clarithromycin and Furazolidone. Changes in symptoms, endoscopic morphology,pathological changes as well as Hp eradication rate and adverse reac- tions before and after treatment were observed in both groups. [Results]l. Main symptoms were relieved in both groups after treatment. There was no significant difference in abdominal pain and abdominal disten- sion between traditional Chinese medicine group and western medicine group （P〈0.05）. But the ameliora- tion of acid reflux in western medicine group was better than traditional Chinese medicine group（P〈0.05） . 2. In the aspect of gastric morphology, the cure rate was 67.5% and the total effective rate was 82. 5% in traditional Chinese medicine group. In western medicine group, the cure rate was 45% and the total effi- ciency rate was 75%. The cure rate of traditional Chinese medicine group outstripped the western medicine group（P〈0.05）, but there was no significant difference in the total efficacy between the two groups （P〈 0.05）. 3. As for pathological changes, the cure rate in traditional Chinese medicine group outstripped the western medicine group（P〈0. 05）. The total efficacy in both groups had no significant difference（P〈 0. 05）. 4. There were no significant differences in Hp eradication rate after treatment and Hp infection rate before treatment between the two groups （P〈0.05）. 5. Four patients of 45 patients with anti-Hp treat- ment had adverse reactions. No patients during Chinese medicine treatment showed adverse reaction. [Conclusion]The curative effect of Jianpi Qinghua Sanyu Decoction on curing raised erosive gastritis is better than the western medicine in endoscopic and pathologic cure rate, which has no adverse reaction, showing exact effect, safety, and trustiness.