烟用香精3-甲基戊酸薄荷酯的合成及分析

Synthesis and Analysis of Cigarette Pennyroyal Essence Menthyl(3-methyl) Pentanoate

合成了新型烟用香精3-甲基戊酸薄荷酯,用IR、GC-MS、1HNMR对产品进行了表征;并对制备反应的反应条件进行了优化,探讨了反应时间、反应温度、催化剂用量和反应物物质的量的比等因素对酯化产率的影响,确定3-甲基戊酸和薄荷醇的物质的量比为1.5∶1,苯作为带水剂,催化剂采用对甲基苯磺酸,用量为反应物3-甲基戊酸和薄荷醇物质的量和的3%,反应加热温度应控制在130℃,反应时间为5 h,产率为73.5%。

A novel cigarette essence, menthyl （3-methyl）pentanoate, was synthesized. The structure of product was characterized by IR , GC- MS and 1HNMR. The influences of reaction factors （ reaction time, reaction temperature, the ratio of amount of catalyst and amount of the react- ants substance of and other factors）were also discussed and optimized. The optimum preparation conditions were n （（3-methyl） pentanoate ） ： n （menthol） = 1.5： 1, benzene as the dewatering reagent, toluane-p-sulfonic acid as catalyst,w （toluene-p-sulfonic acid） 3% , reaction tempera- ture 130℃ and reaction time 5 h. The yield was 73.5%.