局部晚期直肠癌术前与术后同步放化疗的疗效比较

Comparison of Preoperative and Postoperative Chemoradiotherapy in the Treatment for Locally Advanced Rectal Cancer

[目的]比较术前同步放化疗与术后同步放化疗对局部晚期中低位直肠癌的临床疗效和不良反应。[方法]收集100例局部晚期中低位直肠癌患者,50例行术前同步放化疗,同期50例先行根治术再行术后同步放化疗,比较两组的保肛率、局部复发率和生存率以及不良反应。[结果]术前同步放化疗的保肛率明显高于术后同步放化疗组,而局部复发率明显低于术后同步放化疗组(P<0.05),3、5年生存率两组间没有差别(P>0.05)。[结论]局部晚期中低位直肠癌术前同步放化疗可以提高保肛率,降低局部复发率,值得临床推广。

[Purpose] To compare the clinical efficacy and side effects of preoperative and postoperative chemoradiotherapy in the treatment for locally advanced rectal cancer.[Methods] A total of 100 patients with locally advanced middle-low rectal cancer were enrolled.Fifty patients received chemoradiotherapy before radical resection,while another 50 patients received chemoradiotherapy after radical resection.Rate of anal reservation,local recurrence rate and overall survival rate were calculated and compared between the two groups.[Results] Rate of anal reservation was higher in preoperative chemoradiotherapy group than that in postoperative chemoradiotherapy group,while local recurrence rate was lower in previous group,with significant difference（P0.05）.3-,5- survival rates were higher in previous group than those in later group,without significant difference（P0.05）.[Conclusion] Preoperative chemoradiotherapy is able to improve the rate of anal reservation and reduce local recurrence rate in the treatment for locally advanced middle-low rectal cancer.It is worthy of clinical promotion.