乏氧/辐射双启动子系统调控的自杀基因放射治疗研究进展

Progress of Hypoxia/radiation Dual-sensitive Promoter Controlling Suicide Gene Expression in Radiotherapy

基因—放射治疗是近年来国际上肿瘤治疗的一个新策略,但由于实体瘤常处于缺氧状态而对放射敏感性低,影响辐射调控序列的转录活性,因此该疗法目前尚未达到理想效果。在治疗基因上游引入乏氧启动子可克服肿瘤乏氧对辐射调控序列转录活性的影响,提高对肿瘤的杀伤效果。全文对辐射诱导、乏氧诱导以及乏氧/辐射双诱导启动子联合自杀基因放射治疗的研究现状、目前存在问题与前景进行综述。

Gene-radiotherapy is a new strategy in the treatment for cancer recently.However,solid tumors are low radio sensitivity due to their regular hypoxia,thus affecting the transcriptional activity of radiation-regulated sequence.Therefore,this therapy fails to produce the desired effects.Introduction of hypoxic promoter into the upstream of the therapeutic gene can overcome the decrease on the transcriptional activity of radiation-regulated sequence due to the hypoxic state of tumor and thus enhance the killing effect on tumor cells.This paper reviews the research status,existing problems and prospect of radiotherapy combined with radiation-induced,hypoxia-induced and hypoxia/radiation double-induced promoters with suicide gene.