先天性心脏病合并肺动脉高压低体质量患儿血浆偶联因子6的含量及意义

CHANGES OF COUPLING FACTOR 6 FOR CONGENITAL HEART DISEASE AND PULMONARY HYPERTENSION IN LOW MASS CHILDREN

目的研究先天性心脏病合并不同程度肺动脉高压患儿血浆中偶联因子6(coupling factor 6,CF6)含量的变化,以探讨CF6在本疾病中的作用。方法收集2011年1月—2012年8月160例先天性心脏病合并不同程度肺动脉高压患儿。随机分为3组,先天性心脏病未合并肺动脉高压组41例为对照组,先天性心脏病合并肺动脉高压但未达到重度肺动脉高压组76例为A组,先天性心脏病合并重度肺动脉高压组43例为B组。应用放射免疫分析法检测不同组别血浆中CF6的含量。结果对照组CF6含量(199.5±44.7)ng/L,A组(168.7±99.8)ng/L,B组(305.4±81.7)ng/L。对照组与A组之间CF6含量差异无统计学意义(P>0.05),B组CF6含量较对照组、A组明显升高(P<0.01)。结论先天性心脏病合并重度肺动脉高压的低体质量患儿血浆中CF6含量明显升高,提示CF6可能在其病理生理过程中发挥重要的作用。

Objective To explore the changes of coupling factor 6 in plasma for congenital heart disease（CHD） complicated with different degrees of pulmonary hypertension in low mass children. Methods A total of 160 patients with CHD complicated with different degrees of pulmonary hypertension from January 2011 to August 2012 were retrospectively analyzed. The 160 cases were divided into three groups： CHD without pulmonary artery hypertension as control group, CHD with pulmonary artery hypertension but not the highest as A group, CHD with the highest pulmonary artery hypertension as B group. The plasma CF6 level was determined by radio immunoassay for three groups. Results CF6 level in control group was （ 199.5 ± 44.7） ng/L, A group （ 168.7 ± 99.8 ） ng/L, B group （ 305.4 ± 81.7 ） ng/L. Control group and A group had no significant difference（ P 〉0.05 ）. CF6 level in B group was obviously higher compared with that of A group and control group, the difference had statistical significance （P 〈 0. O1 ）. Conclusion The plasma CF6 level is obviously increased in CHD with the highest pulmonary artery hypertension. CF6 may play an important role in the pathogenesis of the disease.